Study On Correlative Risk Factors Of Mild Cognitive Impairment In Acute Small Artery Occlusion

Objective: The paper is to assess correlative risk factors for mild cognitive impairment(MCI)in acute small artery occlusion(SAO)by univariate and multivariate analysis.Then exploring controllable factors that may delay the occurrence of cognitive impairment.Motheds: The patients who were diagnosed as acute SAO were collected from inpatient or outpatient in neurological department of Affiliated Hospital of Inner Mongolia University for Nationalities during November 2015 to November 2016.Patients were assigned into the MCI group 60 cases and no cognitive impairment(NCI)group 59 cases by mini mental state examination and montreal cognitive assessment(Mo CA).The general clinical data,experimental biochemical indexes,carotid artery ultrasound,the number and location of cerebral lesions on MRI were recorded.The SPSS 22.0 statistical software package was applied between MCI group and NCI group comparison of data to analyse the correlative risk factors.Results: 1.Univariate analysis showed that hypertension,diabetes,hyperlipidemia,age,Mo CA scores,triglyceride,serum creatinine and fibrinogen were significantly different in two groups comparison(p < 0.05);2.Multivariate analysis showed that hyperlipidemia was an independent risk factor for MCI with acute SAO;3.There was a significant difference between below primary school level and above secondary school level in Mo CA scores of the MCI group and NCI group(p<0.05).There was a positive correlation between education level and Mo CA scores in MCI group(r=0.460),and the difference was statistically significant(p < 0.01);4.The incidence of arteria carotis communis plaque had a significant difference(p=0.012)in comparison between MCI group and NCI group.The incidence rate of intima-media thickness,plaque of carotid,unilateral carotid artery,bilateral carotid artery,bifurcation of carotid artery and the plaque of internal carotid artery had no significant difference(p>0.05);5.The incidence rate of lesions of the right side and bilateral sides had a significant difference in comparison between MCI and NCI group.There was no significant difference at the incidence rate of single,multiple and left distribution;6.The number of MRI lesions comparison had a significant difference in two groups comparison(p=0.002).There wasa significant difference in the incidence rate of pons lesions and periventricular lesions(p<0.05).There was no significant difference in the incidence of lesions of the medulla oblongata,cerebellum,thalamus,basal ganglia,centrum semiovale,frontal lobe,parietal-occipital lobe and temporal lobe at two groups comparison(p>0.05).Conclusions: Age,hypertension,diabetes,hyperlipidemia,triglyceride,serum creatinine and fibrinogen are possible risk factors of MCI with acute SAO,while hyperlipidemia is an independent risk factor.The level of education,the incident site of carotid plaque,lacunar infarction lesion distribution,location and number may be related to MCI with acute SAO.