Clinical Study Of Tumor Markers Combined Detection In Early Diagnosis And Prognosis Judgment Of Gastric Cancer

Background and Objective:Gastric cancer is one of the most common malignant tumor in the world,and gastric cancer of digestive tract malignant tumor incidence in our country the first place,and had very high mortality rate.Early detection is the primary way to improve the cure rate and improve survival in patients with gastric cancer.On the early diagnosis,serologic screening for early diagnosis of gastric cancer and serology tumor marker for the prognosis of clinical research,it has been an important and hot topic of clinical research.The purpose of this study was to further study and understanding of tumor marker combined detection for the early diagnosis and prognosis judgment value of gastric cancer.Subjects and Methods:Select 240 patients with stomach related diseases in Hangzhou tumor hospital during March 2008 to November 2008 for the first time of see a doctor,80 cases confirmed by pathology of gastric cancer patients as observation group,80 cases of patients with severe atypical hyperplasia with chronic atrophic gastritis in CAGD group,80 cases of normal gastric mucosa or superficial gastritis patients as control group.General condition of patients,disease diagnosis,staging and pathologic differentiation degree,liver metastasis,and serum tumor marker CA19-9,CA724 and CA242,CEA and AFP case collection and extraction.Research CA19-9,CA724 and CA242,CEA and AFP five tumor markers joint inspection in the value of early clinical diagnosis and prognosis of gastric cancer.Using SPSS 18.0 software for statistical analysis,Quantitative data is expressed x ± s,data using t test and chi-square test,P<0.05 for the difference was statistically significant.Results:This study completed the reservation of 240 cases of data collection,of which 80 cases were confirmed by pathology of gastric cancer patients as observation group,80 cases of patients with severe atypical hyperplasia with chronic atrophic gastritis in CAGD group and 80 cases of normal gastric mucosa or superficial gastritis patients as control group.Observation group,65 cases of male,female 15 cases,the median age of 59 years old;CAGD group 41 cases of male,female 39 cases,median age 63 years old;In the control group 43 cases of male,female 37 cases,aged 43 years old.Observation group CEA averaged 31.16±64.82 ng/mL,CA242 was 44.85 ± 123.54 U/mL,CA19-9 was 768.66 ± 2358.88 U/mL,CA724 was 19.04 ± 38.41 U/mL,AFP was 342.56±2708.83 ng/mL,significantly higher than the CAGD group and the control group,with statistical differences.In the gastric cancer group,according to the degree of differentiation,poorly differentiated group indicator of Cal 9-9,CA724,AFP positive rate were significantly higher than in high differentiation group,significant difference(P<0.05).According to the presence of liver metastasis,liver metastasis group of Cal 99,CA724,CEA and AFP positive rate were significantly higher than that of without liver metastases group,significant difference(P<0.05).According to the clinical stage,the stage ? in Cal 9-9,Ca242,CA724 and CEA were higher than the ?-? stage,obvious difference(P<0.05),stage IV in Ca19-9,Ca242,CA724,CEA and AFP were higher than stage ?-?,obvious difference(P<0.05).CEA single test positive rate was highest(52.5%),specificity of 90.91%.Five tumor markers joint inspection of the positive rate was 71.25%,specificity of 88.89%,five measures of tumor joint detection positive rate is higher than single inspection,obvious difference(P<0.05).AFP positive rate in high differentiation group and moderately differentiated vs poorly differentiated groups,and have no liver metastasis vs liver metastasis group,had significant difference(P<0.05),and has reference significance to the prompt presence of liver metastasis.Conclusions:More men than women had gastric cancer.Gastric cancer patients of Ca19-9,Ca242,CA724,CEA and AFP were significantly higher than those of patients with severe atypical hyperplasia with chronic atrophic gastritis and normal people,diagnosis and differential.Rise of Ca19-9,CA724 and CA242,CEA and AFP prompted worse tumor differentiation,late stage,has prognostic value.AFP positive has reference significance to the prompt presence of liver metastasis.Five measures of tumor and positive rate of joint detection was obviously higher than that of single?But this study is a retrospective study,therefore,prospective clinical studies are needed in the future to further study and validation.