| Objectives:To study the expression of CD151 and matrix metalloproteinase-9(MMP-9)in pancreatic carcinoma and their relationship.Their relationship with clinicopathologic factors were analysed and their clinical significances were evaluated.Methods:The expression of CD151 and matrix metalloproteinase-9(MMP-9)were detected by immunohistochemical technique in 45 cases of pancreatic carcinoma and 10 cases of non-tumor pancreatic tissues.The relationship between their expression and the clinical pathological characteristics were also analyzed statistically.Results:1.The positive expression rates of CD151 were 51.1%(23/45),showing a significant difference between pancreatic carcinoma and non-tumor pancreatic tissues(p<0.05).The expression of CD151 was significantly associated with lymphatic metastasis and TNM staging,but was not associated with age,gender,histological grade,tumor site and tumor size.2.The positive expression rates of MMP-9 were 64.4%(29/45),showing a significant difference between pancreatic carcinoma and non-tumor pancreatic tissues(p<0.05).The expression of MMP-9 was significantly associated with lymphatic metastasis and TNM staging,but was not associated with age,gender,histological grade,tumor site and tumor size.3.The expression of CD151,MMP-9 was positively associated in pancreatic carcinoma(p<0.05).Conclusions:1.There are overexpressions of CD151 in pancreatic carcinoma,showing a significant difference between pancreatic carcinoma and non-tumor pancreatic tissues.Expressions of CD151 was associated with lymphatic metastasis and TNM staging.2.There are overexpressions of MMP-9 in pancreatic carcinoma,showing a significant difference between pancreatic carcinoma and non-tumor pancreatic tissues.Expressions of MMP-9 was associated with lymphatic metastasis and TNM staging.3.The expression of CD151,MMP-9 were positively associated in pancreatic carcinoma,their expressions may contribute to the development and metastase of pancreatic carcinoma. |
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