The Clinical Research Of 2% Hydroxypropyl Methyl Cellulose During Pterygium Surgery On Postoperative Dry Eye Symptoms And Tear Film Recovery

Objective:To investigate the influence of 2%hydroxypropyl methyl cellulose(HPMC)during pterygium surgery on postoperative dry eye symptoms and tear film recovery at early peroid.Methods:Patients with primary pterygium who underwent pterygium excision combined with autologous corneal limbal stem cell transplantation were enrolled.The patients were randomized divided into the study group and the control group using random number table according to the usage of 2%HPMC intraoperatively.Ocular surface disease index(OSDI)questionnaire,subjective symptom questionnaire,break-up time(BUT),Schirmer testing Ⅰ(STI)and fluorescein staining(FI)were sequentially evaluated preoperatively and postoperatively at 1 day,10 days,and 30 days and were statistically analyzed.Results:58 eyes from 58 patients with similar baseline characteristics were enrolled in this study including 27 males and 31 females with an average age of 58.7±4.39 years.The number of eyes enrolled in the study group and the control group were 28 and 30,respectively.There were no statistical difference in OSDI value and subjective symptoms between the two groups(P>0.05).TBUT value at postoperative 1 day(7.804±4.038s)and 10 days(8.217±3.449s)were higher in the study group than that in the control group(postoperative 1 day:5.940±3.024s;10 days:6.208±3.192s),with significant difference(P<0.05).STI value at postoperative 30 days were higher in the control group,with significant difference(P<0.05).Fluorescein staining score at 1 day in the study group(4.785±2.409)was lower than in the control group(6.733±3.393),which was also different statistically(P=0.005).Conclusion:Usage of 2%HPMC during pterygium surgery to keep the corneal moist could improve the ocular surface status at early period,be beneficial to early postoperative recovery of tear film function,and promote the repair of corneal epithelium.