Study On The Relationship Among The Correlation Of Maternal-fetal Amino Acid Levels,Weight Gain During Pregnancy And Neonatal Weight

Objective To explore the correlation between maternal-fetal amino acid and the relationship between their levels and weight gain during pregnancy,birth weight.They recommend a reasonable intake of amino acids during pregnancy.That is conductive to reduce the incidence of abnormal weight children and control diet during pregnancy.Methods Pregnant women and their newborns in Hefei City Maternal and Child Health Hospital were selected for the study.They signed informed consent and their baseline,weight gain during pregnancy and their baby’s birth data,venous blood and their babies’ cord blood were collected.There were 69 objects who were included in the study.We used cation chromatography,post-Column Derivatization with Ninhydrin techniques to test the level of free amino acids in plasma of the pregnant women and the umbilical cord.According to pregnancy weight gain,objects were divided into normal weight gain during pregnancy group(group NGWG)and excessive weight gain during pregnancy group(group EGWG);according to newborn birth weight,objects were divided into low birth weight group(group LBW),middle birth weight group(group NBW)and high birth weight group(group HBW).We explored the differences of the level of free amino acids on plasma of the pregnant women and the umbilical cord among the groups,analyzed the pre-pregnancy BMI,weight gain during pregnancy and newborn birth weight with maternal-fetal amino acids and maternal-fetal transport.Results(1)Comparison of amino acids on maternal and cord blood: the essential amino acids(EAA): the levels of Thr,Val,Ile,Leu,Lys and sum of EAA on maternal blood were significantly lower than those on cord blood(p<0.05);non-essential amino acids: the levels of Tau,Ser,Asn,Gly,Ala,3Mehis,Hylys,Orn,BCAA and NEAA on maternal blood were significantly lower than those on cord blood(p<0.05),but the levels of Cit and EOHNH2 on maternal blood were significantly higher than those on cord blood(p<0.05).There was no significant difference in the levels of other amino acids between maternal blood and cord blood(p>0.05).(2)The relationship between amino acid on maternal and umbilical blood: 9 kinds of essential amino acids on maternal and umbilical blood are positively correlation(p<0.05);for non-essential amino acids,amino acids on maternal and umbilical blood are positively correlation(p<0.05)except P-Ser,Urea,Asp and a-ABA(p<0.05).(3)Effect of weight gain during pregnancy on amino acids of maternal and cord blood: Except for Sar,whose level in group NGWG on cord blood was significantly higher than group EGWG(p<0.05),other amino acids on maternal and cord blood in the two groups were no statistically significant difference.(4)The relationship between neonatal birth weight and amino acid on maternal blood and cord blood: for essential amino acid on maternal blood,Val level was significantly different(p<0.05)among the three groups.Val level in group NBW was significantly higher than group LBW and group HBW;for maternal nonessential amino acids,3Mehis,Pro and BCAA level were significant differences among the three groups.3Mehis,BCAA level in group NBW was significantly higher than group LBW and group HBW;Pro levels in group NBW was significantly higher than group LBW;for essential amino acids on cord blood,EAA was significantly difference(p<0.05)among the three groups,EAA level in group NBW was significantly higher than group LBW;for non-essential amino acids on cord blood,Cystha,3Mehis and Pro levels were significant different among the three groups,Cystha,3Mehis level in group NBW was significantly higher than group LBW,Pro level in group NBW were significantly higher than group LBW and group HBW.Conclusion Overall,the levels of most amino acid on cord blood were higher than that of maternal blood,and the amino acid levels of maternal fetus had a good correlation.Pregnant weight gain on maternal and cord blood amino acid has little effect,it may be due to people who were higher pre-pregnancy weight paid more attention to less weight gain.There were also differences in birth weight and amino acid levels between maternal and cord blood.This suggests that pregnant women should be reasonable diet to control the intake of amino acids that mothers produce healthy development of a good pregnancy outcomes and newborn.