Effectiveness Study Of The Antiretroviral Therapy On PLWHA In Huaibei

AIDS is called acquired immundeficiency syndrome,is caused by human immunodeficiency virus(HIV)infection is given priority to with T cell immune function defects of a kind of immune deficiency disease.HIV itself does not directly,but after the infection of the immune system by HIV damage,its opportunity infection rates rise,therefore even die.Since 1981,the first report of AIDS throughout the world at an alarming rate spread and spread,to the development of many countries and regions has brought serious harm.In1985 found the first case of HIV infected people in china,since then the spread of AIDS in China showed a trend of rapid growth.Human beings fight against HIV/AIDS for decades,in constant exploration,significant progress has been made in the treatment of AIDS.And efficient combination antiretroviral therapy(HAART)in the clinical application of the AIDS into a chronic infectious disease can be controlled.In response to the rise of AIDS morbidity and mortality,the Chinese government actively response to the call of the United Nations and the world health organization,the HIV treatment as a public health strategy to curb HIV/AIDS epidemic.Huaibei city from 2003 began to actively promote national free AIDS antiviral treatment,HIV/AIDS prevention and control work has achieved obvious results.To evaluate the 2003 ~ 2013 PLWHA receive antiviral treatment effect,this topic proposed by analyzing the PLWHA treatment of monitoring data,and discusses factors affecting the effects of antiviral therapy,which will provide a scientific basis for further improve the effect of antiviral therapy.Objective Analysis of huaibei city from 2003 to 2013 HIV/AIDS antiviral treatment in PLWHA with monitoring data,Evaluation of antiviral treatment effect,and discusses factors affecting the effects of antiviral therapy,which will provide a scientific basis for further improve the effect of antiviral therapy.Methods Data in this study is derived from the system of disease prevention and control of AIDS in China comprehensive AIDS prevention and control of information system is derived,and patient follow-up treatment basic situation table,table data(Excel2003 version),and the logic check.Including the treatment of patients with basic situation,the physical examination results,CD4+T lymphocyte count,viral load(VL),medication compliance and other data.Export data from the national network for system(Excel2003 version)and logic check.Data analysis by SPSS 16.0 software.Two sample mean comparison using t test,two sample rate compared with chi-square test and inspection level of ? = 0.05.Survival analysis is estimated based on the life table method.Results Huaibei city from 2003 to 2013 by the end of the cumulative receive free AIDS antiviral treatment in 318 cases,free AIDS antiviral treatment covers the whole city.Minimum age 8 years,the biggest age 75 years,mean age 44.4±11.2 years,mainly in the prime of life.Men with an average age of 43.6±11.6 years of age,female and the average age of 45.5±10.7 years old,and there was no statistically significant difference(t = 1.492,P = 1.492).182 cases of men,136 cases of women,men and women sex ratio of 1.34: l.Infection is mainly by Past blood collecting and supplying transmission,the second is sex transmitted between men and women,reason is the paid blood donation act and the spouse sexually transmitted.Receive antiviral treatment after 12 months of CD4+T lymphocyte count mean different levels increase;With the increase of treatment time,a gradual increase in the proportion of viral load is lower than detection logoff,viral load suppression rate of 80.2%,over time more than 12 months viral load suppression ratio tends to be stable,the treatment of patients with virus inhibition rate year after year to improve overall(?2trend= 10.112,P = 0.039).Maintenance treatment rates were 93% at 1 year,2 year survival rate was 92%,the rates were 91% at3 years and 4 years of survival rate was 88%,and 5-year survival rate was 88%,six years of survival rate is 88%,7 years of survival rate of 87%.At 1 year survival rate continued to decline,and deaths occurred mainly in the treatment of the first year.Greatly increased PLWHA medication adherence,statistics found that in the past three months medication adherence medicine accounted for 100% of the total 95% or greater number.Conclusion PLWHA with antiviral treatment effect significantly in huaibei city,CD4+T lymphocyte count rise year by year,the AIDS virus contained.PLWHA survival time increases,the natural life is extended.Early detection,early detection,early treatment can improve the effect of antiviral therapy.Through effective antiviral treatment to reduce the morbidity and mortality of PLWHA,and to reduce the spread of HIV/AIDS.