| BackgroundRecently,the incidence of obesity increased world widely.Obesity has become a serious public health problem globally.According to the reports on the nutrition and chronic diseases among residents in China in2015,the incidences of overweight and obesity were 30.1% and 11.9% in adults,and 9.6% and 6.4% in children and adolescent respectively.Obesity is a risk factor of chronic metabolic diseases,such as high blood pressure,type 2 diabetes mellitus,and cardiovascular disease.Chili is widely consumed.Capsaicin,which is the major pungent principle in the chili,has many biological effects.Research show that dietary consumption of chili can increase satiety,accelerate energy metabolism,and may reduce weight.Animal experiments show that capsaicin can reduce weight in obese mice,improve the energy metabolism and lipid metabolism.However,the anti-obesity effect of capsaicin on obesity human and the influence on the body composition are still unclear.Through a randomized control clinical trial,our study aim to evaluate the effect of capsaicin capsules on the human body composition,fasting serum glucose and lipids levels in overweight and obese adults.Subjects and methodsThis study recruited overweight and obese adults.Chinese adults with a body mass index(BMI)higher than or equal to 24 was considered as overweight,and a BMI higher than or equal to 28 was considered as obesity.Twenty subjects were enrolled from the medical examination center in the Southwest Hospital,Chongqing.In a randomized,double-blind,control clinical trial,twenty subjects were randomly divided into capsaicin group(n=10)and control group(n=10).The participants in the capsaicin group consumed the capsaicin capsules and the participants in the control group consumed the control capsules for 4 weeks.All subjects were instructed to consume two capsules twice daily.The intervention doses of capsaicin were 4 mg/d and 0.05 mg/d in the capsaicin group and control group,respectively.The protocol was approved by the Medical Ethics Committee of Third Military Medical University.All participants provided written informed consent.All subjects were asked to complete a 3 d record of their food intake,semi-quantitative food frequency questionnaire(SQFFQ)and a questionnaire regarding lifestyle,disease history,medication,and nutrient supplements.Human body composition was measured using Inbody 720 body composition analyzer(Biospace company,South Korea).Fasting serum glucose and lipids(triglycerides,total cholesterol,low density lipoprotein cholesterol and high density lipoprotein cholesterol)were analyzed by an automatic biochemical analyzer(AU2700,Olympus,Japan).All statistical analyses used SPSS software.ResultsAll subjects finished the trial.No adverse reactions occurred during this trial.After 4-week intervention,BMI levels significantly reduced by 0.19 Kg/m2(P = 0.015)in the capsaicin group,while the weight and basal metabolic rate did not change.Additionally,the muscle mass of right lower limb muscle in the capsaicin group significantly increased by 0.06 Kg(P = 0.033).In addition,the degree of obesity and visceral fat area index in the capsaicin group significantly decreased by 0.86%(P = 0.015)and 4.46 cm2(P = 0.026).After 4 weeks of intervention,fasting serum triglyceride levels in the capsaicin group were significantly lower than that in the control group(P = 0.01).Fating serum total cholesterol levels were significantly reduced by 1.00 mmol/L(P = 0.03)in the capsaicin group.Conclusions(1)Capsaicin capsules supplementation for 4 weeks significantly reduced the BMI,degree of obesity and visceral fat area in overweight and obesity adults,while increased the muscle mass of the right lower limb;(2)Capsaicin capsules supplementation for 4 weeks significantly decreased fasting levels of triglycerides and total cholesterol in overweight and obese adults. |
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