| Objective: through analyzing the clinical data of Crohn's disease who were under treatment in first classified 3A comprehensive hospital in jilin from 2010 to 2016, in order to master the incidence trend and clinical epidemiological characteristics of Crohn's disease, improve the clinician's emphasis and diagnose level on Crohn's disease and to provide the theory basis for the clinical diagnosis and treatment of Crohn's disease.Methods: I collected the clinical data from January 1, 2010 to July 31, 2016 of 75 inpatients who diagnosed for Crohn's disease at China-Japan Unionhospital of Jilin University. The date included general situation(the first clinic time, sex, age, smoking habit, alcohol drinking habit operation history, disease family history and so on), clinical features(clinical manifestation, diseased region, complication, extra-intestinal manifantation, data of laboratory examination and treatment mean). The data were analyzed by Epi Data3.0 software and SPSS21.0 statistical software to describe the patient's disease characteristics.result:1.75 Crohn's disease patients, including 45 males and 30 females, male to female ratio of 1.5: 1. The youngest was 13 years old, the maximum was 75 years old, average age was 38.88 ± 16.38 years old, of which 20 to 29-year-old group was the biggest proportion accounting for 22.7%. The number of patients with Crohn's disease increased year by year, and the number of patients admitted in 2014 and 2015 was higher than that from 2010 to 2013. The incidence season was mainly summer(31.8%).2. 92.0% of the patients diet were affected, 48.0% of the patients sleeping were affected. 21.3% of patients had smoking habits, 9.3% of patients had drinking habits.3. Patients with family history of Crohn's disease was 3(4.0%). surgery histories were total of 57, of which appendicitis surgery was maximum(38.6%).4. The mainly digestive system symptom of patients were bellyache(84.0%), abdominal distension(52.0%), diarrhea(48.0%); 38(50.7%) patients had different degrees of fever; 22(29.3%) had fatigue. Terminal(42.7%) and colonic(41.3%) were the most common lesion sites of Crohn's disease. The first three extra-intestinal manifestation in proper order were hepatic and gall disease(17.3%), mucocutaneous disease(dental ulcers 13.3%) and injury of joint(9.3%).5. The mainly complication of Crohn disease was enterostenosis was 44(58.7%) samples, 1 samples(1.3%) occurred cancer. 40.0% patients relapse the disease.6. the Crohn's disease affected the nutritional status of the patients, 32(42.7%) patients' BMI were less than 18.5kg/m2, 10(13.3%) patients with malnutrition, 37(49.3%)patients with weight losing more than. There were 48(64.0%) patients with different degree of anemia.7. White blood cell value of 34(45.3%) samples were anomalous; hemoglobin value of 51(68.0%) samples were anomalous; total protein value of 29(38.6%) samples were anomalous; albumin value of 41(54.7%) samples were anomalous;. Among the 41 patients with erythrocyte sedimentation, 37(90.2%) patients had accelerated erythrocyte sedimentation rate(ESR) in the first hour hour. Among the 44 patients with C-reactive protein, 39(88.3%) patients had elevated C-reactive protein. Sodium ion of 30(40.0%) samples were lower than abnormal; potassium ion of 10(13.3%) samples were lower than abnormal; calcium of 19(25.3%) samples were lower than abnormal;among 73 patients who had iron ion detection index,there were 51(69.9%) samples lower than normal.conclusion:1. In this survey, 75 samples of Crohn's disease, the average age of diagnosis was 38.88 ± 16.38 years old, 20 to 29 age group people are susceptible population; male to female ratio is 1.5: 1; the number of patients increased year by year, summer is the occurred frequently season of Crohn's disease; 21.3% of patients had smoking habits, 9.3% of patients had drinking habits; the patients diet and sleeping were affected.2. Patients with family history of Crohn's disease was 4.0%. surgery histories were maximum accounting for 38.6%.3. Crohn's disease mainly clinical manifestations of bellyache, abdominal distension, diarrhea with fever and weight loss; the mainly sites of incidence were the terminal ileum and colon-based; mainly extra-intestinal manifestation were hepatic and gall disease, mucocutaneous disease and dental ulcers.The mainly complication of Crohn disease was enterostenosis; 40.0% patients relapse the disease.4. white blood cell values increased erythrocyte sedimentation rate, C-reactive protein value increased, hemoglobin, iron and prealbumin values decreased.5. Patients were mostly slim, accounted for about half of patients weight loss and malnutrition accounted for 13.3%. There were 48(64.0%) patients with different degree of anemia... |
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