Fresh Transfer Outcome Predicts The Success Of A Subsequent Frozen Transfer Outcome

Objective The objective of this retrospective analysis was to assess whether the outcomes of fresh embryo transfer cycles are predictive of the chances for pregnancy and live birth in subsequent frozen embryo transfer cycles using sibling embryos from the same retrieval, explore the oocyte development potential of the same cohort.Methods We analysed all cycles with fresh and frozen embryo performed during the years 2012/01-2015/03 at the reproductive medicine center of Ningxia medical university. Inclusion criteria: 1. Normal ovulation function(ultrasonic monitoring merger luteal phase progesterone level tests confirmed); 2. The disease because of tubal factor infertility, male factors; 3. The ovarian reserve function was normal CD3: FSH < 15 iu/ml. Eliminate cycles of donor oocytes and embryos derived from the different cycles. Ovarian stimulation protocols in fresh IVF cycles consisted of down-regulation with leuprolide acetate at doses of 0.5-0.75 mg starting in the mid-luteal phase of the preceding menstrual cycle, followed by exclusive use of recombinant FSH 150-450 iu/d, to the follicle diameter at least two 18 mm, intramuscular injection human chorionic gonadotropin, pick up the oocytes after 36 h. According to the fresh embryo transfer pregnancy outcomes are divided into two groups, group A was achieved pregnancy in fresh embryo transfer cycles, by reason of miscarriages or planning a second child and then proceed frozen embryo transfer, group B was not achieved pregnancy in fresh embryo transfer cycles, proceed frozen embryo transfer later, compare group A and group B clinical pregnancy rate and live birth rates in subsequent frozen embryo transfer cycles.Results Fresh embryo number frozen embryos in patients with pregnancy group(P = 0.016), high quality embryo number(P = 0.001), high quality embryo rate(P = 0.01) were higher than fresh embryos transfer non-pregnancy group, the difference had statistical significance(P < 0.05).In the frozen cycles, the clinical pregnancy rate was 62.5% in group A was significantly higher than that of group B clinical pregnancy rate was 44.0%(P < 0.05).Patients of group The live-birth rate is 55.36% in group A was higher than that of group B live-birth rate was 38.67%, P = 0.111, however, there was no statistically significant difference.Conclusion Fresh embryo transfer with successful pregnancy have a higher clinical pregnancy rate and live birth rate in frozen embryo tranfer, prompt the oocyte has a similar development potential of the same cohort, namely fresh embryo transfer with successful outcome have a positive predictive value for frozen embry transfer.