Experimental Study Of ?-TCP/CGF Compounds Promote Healing Mandibular Defects In Rabbits

Objective:In this experiment, ?- tricalcium phosphate(?-TCP) is used as a 3-dbone scaffold, which was mixed with concentrated growth factor(CGF) to prepare a compound(?-TCP / CGF), applied in the model of mandibular bone defects in rabbits. To study the effects ofthe compound on repairing and treating bone defects.Trying to find a safe and effective method which can accelerate bone regeneration,and providing a reliable theoretical basis for the future clinical applications.Methods:24 healthy male rabbits, with 5mm diameter circular bone defects in the mandibular angle?respectively fillingrequired biological material in bone defects. According to filled materials are divided into four groups: control group(Group A): Bone defects unfilled any materials; ?-TCP Group(Group B): Filled the bone defects with?-TCP; CGF Group(Group C): filled the bone defects with full CGF; Composite Group(Group D): filled the bone defects with ?-TCP / CGF Compounds.After operation for 4/8/12 weeks, those samples need X-ray examination and made into decalcified sections, which then are statistically analyzed the osteogenic areas using the histomorphometric analysis method.Results:I. At the same observation time, the osteogenesis results of Group D's result is statistically different to Group A, B and C. II. At different observation time, the osteogenesis results of the same group are: Group A, B, C and D's results are all statistically different.Conclusions:I.?-TCP / CFG Compoundshave a significant osteogenic effect. II.Only ues?-TCP has not a significant osteogenic effect.?. Only ues CGFhas not a significant osteogenic effect.