Prevalence Of Thyroid Disorder And Associated Risk Factors With Different Glycemic Status Among Northern Chinese Adults

Diabetes mellitus(DM) and thyroid dysfunction(TD) always found to appear simultaneously as thyroid hormones can influence glucose control through a variety of actions on intermediary metabolism. Nevertheless, there is little study on the prevalence of thyroid dysfunction among prediabetic patients(PD). On account of this,The objective of this study was to investigate whether abnormal glycemic status(diabetes and prediabetes) is associated with the increased prevalence of thyroid disorder and to identify factors that effect the risk of TD among individuals with different glycemic status in Northern China.Methods 10860 adult participants were enrolled in the cross-sectional study based on REACTION study and underwent laboratory evaluation. They were divided into three groups by the glycemic level according to American Diabetes Association 2010 criteria in order to investigate the different prevalence of TD in each group, as well as the risk factors on the presence of TD.Results The study population comprised 2994 diabetic patients(27.57%) and 6386 prediabetic patients(58.80%) with mean age of 55.37±8.82 years. The overall prevalence of TD was 13.52 %. Compared to those with normal glucose status(8.11%), TD was more common in diabetic patients(15.97%), as well as in prediabetic patients(13.48 %)(P<0.001). The prevalence of cardiac-cerebral vascular disease(CCVD) was significantly higher in diabetic patients with thyroid disorder(34.12%) than that in those without ones(26.50%), respectively(P=0.02). In the condition of TD, the prevalence of CCVD was significantly higher in diabetic patients than that in prediabetic patients(P<0.01). According to binary logistic regression, gender is the only common risk factor and the impact of female gender related to the presence of TD is even more profound in diabetic patients than that in other glucose status.Conclusion Considering the high prevalence of CCVD which is arising from an undiagnosed TD, we suggested that screening for TD among patients with DM or PD should be regularly performed, especially in female patients.