Meta-analysis Of The Correlation Between Hyperuricemia And Acute Kidney Injury

Objective To explore whether hyperuricemia is correlated with acute kidney injury(AKI) and act as an independent risk factor in AKI. By using Meta-analysis.Methods Through Pub Med / MEDLINE, Advanced search, Free Medical Journals, Cochrane Library, China How Net, Wanfang Data, Springer,Embase, Chinese How Net, Wanfang ect database,we collected literatures published from May 1990 to May 2015,in both English and Chinese,which related to the hyperuricemia and acute kidney injury.These literatures included the type of case-control studies and the cohort studies. The articles were selected according to the criteria of exclusion and inclusion.The selected articles were analyzed and evaluated by using the method of the quality assessment of medical literature which was described in the Cochrane Collaboration medical literature.Meta-analysis was carried out by using a systematic review of the analysis, with an odds ratio(odds ratio, OR) as the effect of value to OR, 95% CI(confidence interval, CI) as the effect size of each interval range. Finally, all datawere analyzed by using Rev Man5.3 software for and evalulated the relationship between hyperuricemia and AKI(acute kidney injury).Results There are four text documents, including two in English and two Chinese(3798 total observed object, which hyperuricemia group 1002 patients, 2796 patients with normal control group).Meta-analysis results are as show follows: comparing the hyperuricemia group with the control group, the risk of acute kidney injury was increased by 4.46 times(OR =4.46,95% CI: 3.22-6.17); the risk of diabetes was significantly increased by 2.34times(OR = 2.34,95% CI: 1.03-5.34); and the e GFR remarkablely decreased( OR = 2.89,95% CI:1.91-4.37).Conclusion The hyperuricemia is one of the risk factors for acute kidney injury..