The Clinical Analysis Of 112 Cases With Borderline Ovarian Tumors

OBJECTIVE: Summarize the clinical features of borderline ovarian tumor(BOT), including clinical characteristics, examination, surgery, chemical therapy and prognosis. Exploring the factor of recurrence.METHODS: 112 cases of clinical data with BOT were analyzed from January2000 to March 2015 in Tianjin Medical University General Hospital, including ages,clinical symptom, imaging, tumor markers, surgery processor, histological types and staging, chemical therapy, recurrence and pregnancy outcome. Carry on the independent-samples T test, ?2test, and Fisher exact test to a analyze the data.RESULTS:Characteristics and symptom: The mean age of 112 BOT patients was50.21±16.90. Cases with history of pregnancy: 82. The BOT clinical symptoms: 38cases(39.2%) had abdominal pain with 11 cases(11.3%) of torsion. 25 cases(25.8%) had abdominal distension or mass. 17 cases(17.5%) had frequent micturition. 4 cases(4.1%) had vagial bleeding. And 16 cases(16.5%)were just found by health examination with no significant symptom.Examinations: All 112 cases had ultrasound examination( Transabdominal or transvaginal). Mixed cystic-solid lesion had found in 46 cases. Solid lesion was found in 5 patients. The average diameter of the tumor was 110.8mm(40mm~400mm).Tumor marker( positive/ all): CA125: 27/102; CA199: 8/56; HE4:1/119.Surgery processor and chemical therapy: All 112 cases underwent surgery therapy. 14 cases had unilateral tumor excision; 22 cases had unilateral adnexectomy;15 cases had bilateral adnexectomy; 26 cases had total hysterosalpingo-oophorectomy;34 cases had omentectomy and total hysterosalpingo-oophorectomy; 68 cases did quick frozen pathological examination, 47(69.12%) had the same result as the postoperation pathological examination. 24 cases had laparoscopic surgery while 88 cases of open surgery. 12 cases that over staging? or the tumor ruptured had chemical chemotherapy. Including TP program, PC program and intraperitoneal cisplatin single-agent chemotherapy. The course of treatment was 4-6 times.Histological types and FIGO staging: Serous BOT, 57 cases; mucinous BOT,52 cases; mixed 3 cases. Staging: Staging?, 102 case(s 91.07%),staging ?, 4 cases(3.92%),staging ?, 6 cases(5.88%). Bilaternal lesion:17 cases. Microinvasion can be found in5 cases. Micropapilla can be found in 5 cases of serous BOT.Prognosis and fertility outcome: 97 cases are in follow-up. The average period range are 51.5 months( 9 ~204months). 5 recurrence cases found. No recurrence cases been found in cases which had been fertility-sparing surgery. The factor of recurrence is related to FIGO staging, micropapilla and microinvasion.CONCLUSION: BOT patients are characterized with early onset, low maglinancy and comparatively good prognosis. Because most of patients had unapparent clinical symptoms, it is contribute to find the change by regular checkups,ultrasound examination and tumor marker examination. The positive rate of quick frozen pathological examination has a high positive rate that can be reference of the extent of surgery. It is safety for the patients who have a desire of fertility to receive fertility-sparing surgery. It should pay more attention to the patients with high staging, micropapilla and microinvasion because of the recurrence.