Study On Atopic Diseases And FLG Genotypes Of Students In One Middle School In Shanghai

Objective:To explore population genotype of FLG gene, prevalence and progress of atopic diseases in adolescent population, as well as their relationship.Methods:All 334 students from 10 to 19 years old in a middle school were included in the study. Clinical symptoms were observed carefully.Atopy related history was inquired one by one. All above were recorded.2ml of venous blood from 285 voluteers were collected for screening of common FLG gene mutations. Five years later, a follow-up was carried out.Results:(1) Five years ago, there were 19 AD patients(5.69%), 14 IV patients(4.19%), 36 allergic rhinitis patients(10.78%), and 4 cases of asthma( 1.20%) in 334 individuals. Twenty-four out of 285 individuals,who participated in FLG gene genotype,carried at least one common FLG mutation(8.42%).(2) 5 years later, a total of 265 cases were successfully follow-up study(69 persons loss,20.66%).There were 13 AD patients(4.68%), 15 IV patients(5.40%), 29 allergic rhinitis patients(8.27%), and 1 cases of asthma(0.36%),respectively.(3) Carriers of common FLG gene mutations in AD, IV and AD plus IV account for20%, 55.6%, and 40%, respectively. FLG gene mutations are not associated with AD, asthma or allergic rhinitis statistically(P>0.05). IV in population associated with FLG mutations(P<0.001).(4)Six cases of19 AD patients go to complete remission 5 years later. Thirteen cases of them improved with SCORAD evaluation decreased. Symptoms disappeared in 7 cases of allergic rhinitis.Conclusion:(1) The rate of common FLG gene mutations in population is8.42%.(2) Among teenagers the prevalence of AD and asthma decreased with age.(3) FLG gene is the semi-dominant gene for IV. The expression of filaggrin is influenced by multiple factors.