| Objectives Using Ultrasound Cardiogram(UCG) for the accurate measurement of ductus arteriosus(DA) in preterm infants, three key parameters, PDAd2, PDAd1 and PDAd are recorded. Using a simplified formula s=PDAd1×PDAd2, calculated s, the central area index of DA, compared with the PDAd, analysis of the correlation between the size of s and the prognosis of PDA, explore whether the use of s to predict the prognosis of PDA is more accurate than the traditional method by measuring the PDA minimum width PDAd to predict the prognosis of PDA, to provide evidence for the clinical use of drug intervention in preterm infants with PDA.Methods Select 127 cases with preterm infants(gestational age < 35 weeks) of the NICU hospitalization patients in Affiliated Hospital of Chengde Medical College from September, 2015 to September, 2014, measure the smallest PDAd of arterial canal and central PDAd1 of arterial canal in the PSSA, measure central PDAd2 of arterial canal section in the SSLA, record other ultrasonic cardiography data at the same time and calculate Da central area's index. According to the closure of the PDAd and drugs usage, the group can be divided into 4 groups, it can be said to be divided into 4 levels. Group 1 is of closed within three days after birth, the measurement data of must be once the ultrasound results after birth; group 2 is closed after a course of medication, the measuring data is respectively measured in the first day and the 4th after birth; the parameters of group 3 are closed after courses of medication, there are measurement data of three times, which is respectively the ultrasound results of the first day, the 4th, the 7th day after birth; the parameters of group 4 is not closed after two courses of treatment before discharge, there are measurement data of 4 times, which is respectively the ultrasound results of the first day, the 4th day, the 7th day and the 10 th day. The data in the same group and the data among four groups are compared and analyzed.Results 1 PDAd1 is obtained from the PSSA section, and PDAd2 is obtained from SSLA section, the data of PDAd2 and PDAd1 is different through the analysis.which is of significant difference, and indicates that the central part of PDA lumen is not round but most of oval. 2(1) There exist significant differences of the first measurements of the PDAd and s among all groups after birth, the average PDAd value from the first group to the 4th group is respectively 1.500, 2.948, 3.544, 5.192, the average s value respectively is2.720, 9.433, 13.301, 28.098, there is a gradual increase trend, which indicates the higher the group level is, DA is not easier to be closed, PDAd and s have similar functions. The results of PDAd and s are significantly different among the three groups. The PDAd and s in the 3rd, 2nd, 4th groups have significant differences, and there is a reducing trend, which indicates that the s and PDAd are reducing, DA has a tendency to close or applying ibuprofen can make PDA smaller.(2) There is a correlation between PDAd and s, r=0.913, P < 0.05. We can see from the correlation analysis that the R value of S is 0.880, and it is greater than R of PDAd 0.679, which shows that the correlation between s and group are better than those of PDAd, P < 0.05 has statistical significance.(3) PDAd, s, LVIDd, MPAd and gender have effect on the grade grouping. Among them, the variable coefficient B value of PDAd, s, MPAd, gender is positive and B value of s is 0.728, and it is significantly higher than B value of 0.226 of PDAd, which indicates that the effect of s in the study of grouping level is significantly higher than that of PDAd, P < 0.05 is considered to be statistically significant. 3(1) The local premature infant: s?2.720 ± 0.638, 95% interval is(1.470, 3.970); PDAd?1.500 ± 0.209 mm, 95% interval is(1.090, 1.910), the DA can close automatically.(2) Local premature infant: s?13.301 ± 2.415, 95% interval is(8.568, 18.034); PDAd < 3.544 ± 0.296 mm, 95% interval is(2.964, 4.124), the drug application can make DA closed.(3) Local premature infant: s?28.098 ± 5.676, 95% interval is(16.973, 39.223); PDAd?5.192 ± 0.495 mm, 95% interval is(4.222, 6.162), the drugs cannot make DA closed.Conclusions 1 s can evaluate the prognosis of premature infants with PDA and to provide reference for clinical medication. 2 s and PDAd have similar effect on evaluating the prognosis of premature infants with PDA, and the s is more accurate. 3 The ibuprofen can reduce DA cross sectional area and the minimum diameter of preterm infants. |
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