The Clinical Feature Of Idiopathic Optic Neuritis

Objects: Retrospectively analysis and summary of the different types of clinical characteristics of idiopathic optic neuritisMethods: We collected the clinical data of hospitalized patients with idiopathic optic neuritis from January 2013 to September 2013. According to the cause, they were classified as MS- ON group, NMOSD- ON group and unknown etiology, then, the clinical data of each group were analyzed.Results: A total of 289 cases of idiopathic optic neuritis were collected, including 75 MS- ON, 99 NMOSD- ON, 115 with unknown etiology. All groups had no statistical differences in age, and the average age of the patients with NMOSD- ON was 33.5 ± 10.7 years old. Women give priority to all groups,and the female incidence in NMOSD- ON group was higher than other groups, the male to female ratio of which was 1:5. 19. Upper respiratory tract infection was the most common inducement of idiopathic optic neuritis, and the incentive rate of MS- ON is higher than the other two groups. NMOSD- ON more easily followed with other autoimmune diseases, such as sjogren's syndrome. The proportion of single and double eye have no statistical difference in all groups, and MS- ON are more likely to have ophthalmodynia than NMOSD-ON. Compared with MS- ON, the degree of visual impairment in NMOSD- ON group is heavier,and the opportunity to recover is much less. The results of fundus examination suggest that the incidence of papillitis in NMOSD-ON group is higher than the rest groups. MRI showed that the optic chiasma could be involved in NMOSD- ON. The examination of immunology showed that the positive rate ANA in NMOSD- ON group is higher than MS – ON,and the positive rate of AQP4 in NMOSD- ON was 86.2%. The nucleated cell count of cerebrospinal fluid in NMOSD- ON group can be significantly increase, but less common in MS- ON. The time of conversion, annual relapse rate,and the first recurrent time have no statistical difference between MS-ON and NMOSD-.ON. That ION with female, normal fundus and abnormal head MRI have a higher risk convert into MS, and complicated with autoimmunic diseases have a higher risk convert into NMO. The risk of recurrence is higher for NMOSD- ON and ION without using immunosuppressant therapyConclusions: There are differences among the different types of idiopathic optic neuritis in clinical characteristics, treatment and prognosis. It is of great significance to diagnosis and treatment earlier.