Study On Relationship Between Expression Of Ki67 And Prognosis In T3 Gastric Adenocarcinoma

Objective Ki67 plays a key role in regulating the cell cycle and has prognostic value for varieties of malignant tumors. But the relationship between expression of Ki67 and T3 gastric adenocarcinoma has not yet been studied. This study aim to explore the relationship between expression of Ki67 and prognosis in Surgically-Resected T3 Gastric Adenocarcinoma. Methods Retrospective analysis of 693 patients with T3 GA who underwent D2 radical resection at a single institution between July 2003 and December 2009 was performed,and postoperative pathology were all T3 stage.Ki67 expression in tumor tissues was examined using immunohistochemistry(IHC);the associations between Ki67 and prognosis/survival outcomes were assessed using the Chi-square test, Kaplan-Meier survival analysis, log-rank test, and univariate and multivariate analysis. Results At the end of the follow-up,496 cases recurred, 494 cases died,and the median time to relapse and the median survival time was 20 months,28 months respectively.High Ki67 expression(IHC score ? 3+) was observed in 335/693(48.34%) of cases. Ki67 expression was significantly associated with distant metastasis, 5-year median recurrence-free survival time in months(MRFST), and 5-year median overall survival time in months(MOST). Median recurrence and overall survival were 20 and 28 months. High Ki67 expression was associated with shorter MRFST(13 vs 27 months, p<0.001) and MOST(21 vs 35 months, p<0.001 compared to low Ki67 expression). Multivariate analysis demonstrated that high Ki67 expression was an independent prognostic factor for an increased risk of recurrence(p=0.001) and distant metastasis(p=0.003) and poorer overall survival(p=5.33×10-5). Conclusions High Ki67 expression was frequently observed in resected T3 GA and was a significant prognostic factor for poor outcome with respect to recurrence, distant metastasis and overall survival. Ki67 may represent a useful prognostic biomarker for resected T3 GA.