Children With Convulsions Serum GFAP And MBP Level Expression And Clinical Significance

Objectives Study the serum expression of glial fibrillary acidic protein(GFAP) and myelin basic protein(MBP) in children with convulsions, and assess the relationship between serum GFAP and MBP expression and brain injury in children with convulsions and clinical significance of the serum GFAP and MBP expression.Methods 232 cases were selected in this study, including 116 convulsion cases and 116non-convulsion cases. According to inducements, convulsion cases were divided into febrile convulsion group, viral encephalitis group and epilepsy group. According to the frequency and duration of convulsion, convulsion cases were divided into convulsion group 1 and convulsion group 2. Enzyme-linked immunosorbent assay(ELISA) was used to assess the expression of MBP and GFAP,then compare differences of serum GFAP and MBP expression between convulsion cases and non-convulsion cases.Results The expression of GFAP and MBP were all higher in convulsion cases than in non-convulsion cases(P<0.01), but there was no difference among febrile convulsion group, viral encephalitis group and epilepsy group(P>0.05). In addition, the expression of GFAP and MBP were higher in convulsion group 2 than convulsion group 1(P<0.01).Conclusions Convulsion could increase serum MBP and GFAP expression and cause brain injury. The severity of brain injury was not associated with inducements of convulsion, but associated with the frequency and duration of convulsion. The more frequency and longer duration of convulsion is,the higher expression of serum GFAP and MBP in children is,and the more severity of brain injury is.MBP and GFAP can be used as the clinical biochemical index of brain injury induced by convulsion.