The Correlation Analysis Between Red Blood Cell Distribution Width(RDW) And Atrial Fibrillation

Objective:To discuss the relationship between Red Blood Cell distribution width(RDW) and atrial fibrillation, and to evaluate whether RDW is an independent risk predictor for atrial fibrillation or not. Methods:(1)116 cases of atrial fibrillation was selected continuously from the Department of Cardiology of the First Affiliated Hospital of Fujian Medical University from May 2014 to July 2015 retrospectively, in which 71 males and 45 females, mean age 64.47 ± 9.77 years(aged 40-86 years). Selected another 105 cases of non-atrial fibrillation as control from the Department of Cardiology and the Cadre Ward during the same period, matched for sex, age and comorbidities, in which 64 males and 41 females, mean age 62.90 ± 9.16 years(aged 39-81 years). Recorded all subjects of clinical data detailedly, including sex, age, comorbidities, blood routine test, clinical chemistry examination and echocardiography, and compared the indicators between two groups.(2)Excluding other non-hypertensive patients in the AF group, remaining 64 cases included in the group of hypertension with AF, in which 37 males and 27 females. Excluding non-hypertensive patients in the control group, remaining 69 cases included in the group of hypertension with non-AF, in which 45 males and 24 females. Compared the indicators between two groups detailedly.(3) According to the duration of atrial fibrillation, AF group was subdivided into paroxysmal AF group and chronic AF group, paroxysmal AF referred within 7 d after the onset of their own or be able to be terminated by intervention. Defined as chronic AF lasting longer than 7 d. Paroxysmal AF are 81 cases and chronic AF are 35 cases, Compared the indicators between two groups detailedly. Results:(1)There were no significant differences in sex, age, combined with hypertension, coronary heart disease, diabetes, stroke, smoking and drug therapy between AF group and control group(P> 0.05). DBIL of AF group was significantly higher than that of control group(P <0.05). The level of RDW, LAD of AF group were 13.44% ± 0.95% and(3.85 ± 0.66)cm. The level of RDW, LAD of the control group were12.99% ± 0.77% and(3.56 ± 0.48)cm. Compared two groups of two indicators and statistical difference was found( all P < 0.01). On single factor correlation analysis, the level of RDW correlated positively with LAD(P <0.05). Multivariate Logistic regression analysis showed that: RDW and LAD both were independent predictor for AF(OR values were 1.833 and 2.588, P <0.05). RDW in predicting the area under the curve of AF is 0.65(95% CI = 0.578 ? 0.723, P <0.05), the best diagnostic Cut-off value was13.25%, the sensitivity and specificity were 54.3% and 73.3%.(2)There were no significant differences in sex, age, combined with coronary heart disease, diabetes, stroke, smoking, and drug therapy between hypertension with AF group and hypertension with non-AF group(P> 0.05). The level of RDW, left atrial diameter(LAD) of hypertension with AF group were 13.40% ± 0.87% and(4.05 ± 0.65)cm. The leve lof RDW, LAD of hypertension with non-AF group were 13.00%± 0.82% and(3.63 ± 0.52)cm. Compared two groups of two indicators and statistical difference was found(P<0.01).On single factor correlation analysis, the level of RDW correlated positively with LAD(P <0.05). Multivariate Logistic regression analysis showed that: RDW and LAD both were independent predictor for hypertension with AF(OR values were 1.720 and 3.272, P <0.05). RDW in predicting in the area under the curve of hypertension with AF was 0.657(95% CI = 0.564?0.751, P <0.05), the best diagnostic Cut-off value was 12.95%, the sensitivity and specificity were 70.3% and 60.9%.(3)Compared with paroxysmal AF and chronic AF, RDW, LAD, TBIL, DBIL. IBIL, combined with diabetes, cerebral stroke of chronic AF were significantly higher than that of paroxysmal AF group(P <0.05). Left ventricular end systolic dimension(LVESD) and Left ventricular ejection fraction(LEVF) of chronic AF were significantly lower than paroxysmal AF group(P <0.05).Conclusions:(1)RDW was closely associated with AF, and RDW may be an independent predictor for AF.(2)RDW was closely associated with hypertension with AF, and RDW may be an independent predictor for hypertension with AF.(3)RDW was closely associated with the severity of AF.RDW of chronic AF was significantly higher than paroxysmal AF.