The Relationship Between Fine Particulate Matter And Premature Rupture Of Membranes

Objective To investigate the relationship between maternal exposure to fine particulate matter(PM2.5)and risk of premature rupture of membranes.Methods The parturients were selected in Fuzhou General Hospital from January 1st to December 31 th 2014. The pregnant women of singleton births with spontaneous onset of labor were selected as the case group and those pregnant women of singleton births without spontaneous onset of labor as the control group. Ambient air quality measurements of mean daily PM2.5 concentration from January to April were provided by Fujian Provincial Environmental Monitoring Center.Each individual PM2.5 exposure was calculated by their detail home addresse.Multivariate Logistic Regression Model was used for the analysis of influence of air pollutants on premature rupture of membranes.Results 1.The mean daily PM2.5 concentration fluctuated wildly from 3 to 165 ug/m3PM2.5 concentration was high in the first quarter while lowest in the third quarter in Fuzhou area. 2.From January to December 2014,a total of 3858 women had single birth in Fuzhou General Hospital of Nanjing Military Command.The incidence of singleton births with premature rupture of membranes was 14.7%,and of singleton births with premature rupture of membranes was 2.3%. 3.According to the inclusion and exclusion criteria,314 pregnant women with singleton births were selected as the case group,441 pregnant women as control group.The average levels of PM2.5 exposed in the pregnant women with premature rupture of membrane during the last-3-months of gestation were separately significantly higher than those in the controls(p<0.05).But PM2.5 exposure in the whole gestation of pregnancy was comparable between the observed and control groups(p>0.05).Using the Multivariate Logistic Regression Model,we found that higher of PM2.5 exposure levels during the last 3 months was,the higher risk of premature rupture of membrane was.Adjusted odds ratios(OR) for each quariile increase in PM2.5 in the last 3 months were 1.72(OR=1.72,95%CI:1.33-2.12).Conclusion Based on the condition of PM2.5 levels in Fuzhou area,maternal exposure to PM2.5 in the last 3 months of pregnancy may be associated with premature rupture of membranes.