| Objective: Our objective was to explore new program of percutaneous lung biopsy of pulmonary nodules through double-needles percutaneous lung puncture biopsy guided by electromagnetic navigation guided animal experimental.Method: The objects were four experimental pigs(Small fragrant pig).Operation method were as follows: 1, made the virtual lesions and scanned for chest CT data: mixed phantom meglumine 10 ml with 50% starch solution of 1:1to form the phantom meglumine starch mixture. Eight virtual lesions be made by both sides of the four pigs lung tissue injected into the phantom meglumine starch mixture that each one was 0.5ml and the average diameter of 1 cm. The reference needle was inserted into near the virtual lesions when pig was under anaesthetic, and then got the pig chest CT data to burn DVD, CT scan parameters: the layer thickness 3 mm;Pitch, 1.375:1;Rotation time, 0.5s. 2, intraoperative lesion location and biopsy: import the chest CT data into the electromagnetic navigation system, then made registration of the electromagnetic navigation coordinate system and the 3D image. calculated the probe relative spatial location of experimental animals and display it in the reconstructed 3D image. Based on this, perform the electromagnetic navigation system guided puncture needle biopsy. 3, Validation of specimen: after cutting needle puncture biopsy, took out the pathologic specimens to stain iodine to judge the accuracy of the positioning biopsy by confirmed whether the cutting organization contains blue areas or not. At the same time, collecte the data of registration error, puncture accuracy and puncture time for statistical analysis.Results: 1, Before the electromagnetic navigation system guided percutaneous lung puncture, the average error of registration precision of 8 cases virtual lesions is1.15±0.04 mm. 2,8 cases were all successful, the puncture accuracy rate was 100%. 3, the average puncture time is 32.75±5.37 min. 4, in the percutaneous lung puncture operation of each virtual lesions, the number of CT scanning is 2-3 times. After puncture, the oozing of blood around cutting needle was 4 cases, with no obvious signs of bleeding, small amounts of pneumothorax was 1 case by CT scan review.Conclusion: 1, the computer aided electromagnetic navigation technology used CT three-dimensional reconstruction imaging for percutaneous lung puncture, can provide the accurate, real-time,three-dimensional reconstruction image to the performer, and it is advantageous to the performer to plan path for puncture by electromagnetic navigation system, it can avoid surrounding blood important vessels, windpipe organization reducing complications. Compared with the traditional CT guided percutaneous lung biopsy, the clinical application of the electromagnetic navigation in percutaneous lung puncture can improve the safety and accuracy and improve the success rate of surgery of nodules, at the same time so as to shorten the puncture time and X-ray exposure time. 2, The animal experiments confirmed that the double stitch electromagnetic navigation guided percutaneous lung biopsy is feasible, and laid a foundation for clinical trials in the next step. |
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