Effects Of Different Exercise Intensity On Fat Metabolism In Type 2 Diabetic Patients

Objective:The study aimed to observe the effects of FATmax and regular exercise intensityon fat metabolism in type 2 diabetic patients.Methods:We selected 24 type 2 diabetic outpatients (glycated hemoglobin^ 7%) from May 2015 to December 2015, who were treated in Department of Endocrinology, Zhongda Hospital. Southeast University, to do the cardiopulmonary exercise test with gas metabolism analysis instrument (K4b2).Then the patients were randomly divided into FATmax group and regular exercise intensity group. We also used theK4b2 to establish maximum fat metabolism intensity exercise program, then patients did exercise with FATmax by power cycling. Regular exercise intensity group were brisk movement, walking speed of 120 to 140steps/min or 100-120 mteres/min (about 60% maximum oxygen uptake). Two kinds of exercise intensity were used to train patients for 3 months, collected and compared biochemical index, weight, BMI, WHR, fat%, inflammatory factors before and after the exercise.Results:1. After3 months, glycated hemoglobin data in both of groups were not statistically significant compared with baseline(P> 0.05).2. After3 months, a significant reduction of TG and LDL were observed in FATmax group; however, no significant change was identified in regular exercise intensity group.HDL and CHOL in both of groups did no differ at baseline (P> 0.05).3. After 3 months, weight, BMI, fat mass, fat% declined significantly of famax exercise training (P<0.05); however, the change of WHR and fat free mass was not statistically significant (P> 0.05). There was a decrease in weight, BMI, WHR, fat mass, fat free mass and fat%, but the changes were not statistically significant (P> 0.05).4. Baseline concentrations of TNF-?andIL-6 were not different among groups. Both of the inflammatory markers related to adipose tissue were significantly changed by 3 months of exercise training, but the change of TNF-?andIL-6among groups not statistically significant (P> 0.05).5. After 3 months, there was an significant increase in VO2max of two group and VO2max/kg in FATmax group, as well as a decrease in HRmax, but the changes were not statistically significant.VO2max and VO2max/kg in FATmax group were raising more than regular exercise intensity group (P<0.05)Conclusion:1. In the same period of time, FATmax exercise was more effective than regular exercise intensity on reducing blood lipid.2. In the same period of time, FATmax exercise has more benefit than regular exercise intensity on fat loss in type 2 diabetic patients.3. In the same period of time, exercise could reduce the chronic inflammatory factors, suggested that exercise could improve the chronic inflammatory state in overweight type 2 diabetic patients.4. In the same period of time, exercise could increase cardio-pulmonary function in type 2 diabetic patients.