Analysis Of The Factors Influencing Anastomotic Leakage After Dixon Operation For Rectal Cancer

Objective The aim of this study was to investigate the incidence and factors associated with anastomotic leakage (AL) after Dixon operation for rectal cancer.Methods The clinical data of 257 patients with rectal cancer who underwent Dixon operation in Zhongda hospital between January 2005 and August 2015 was collected. Univariate analysis and Logistic regression analysis were performed to determine the risk factors for AL.Results AL occurred in 16 patiens, and its rate was 6.23%. The accounted rate of AL was 5.48% in male patients vs.7.21%in female patients(P=0.570); was 6.45% in patients with diabetes vs. 6.19% in patients without diabetes(P=1.000); was 8.57% in patients with hypoproteinemia vs.5.35% in patients without hypoproteinemia preoperatively(P=0.508); was 15.79% in patients with laparoscopic assisted resection vs.5.46% in patients without laparoscopic assisted resection(P=0.194); was 3.33% in patients with defunctioning stoma vs.6.61% in patients without defunctioning stoma(P=0.768); was 0% in patients with tumor above peritoneal reflection vs.8.89% in patients with tumor on or below peritoneal reflection (P=0.016); was 10.96% in patients with tumor of T0-T2 stage vs.4.35% in patients with tumor of T3-T4 stage(P=0.091); was 5.13% in patients with tumor of NO stage vs.7.92% in patients with tumor of N1-N2 stage(P=0.365); was 5.04% in patients with tumor of M0 stage vs.21.05% in patients with tumor of M1 stage(P=0.022, OR=5.022,95%CI:1.44?17.47). The mean age was 60±25 years in patients with AL and was 65±17 years in patients without AL(P=0.378). The average distance between distal margin and tumor edge was 2.00±1.75cm in patients with AL and was 2.00±2.00cm in patients without AL(P=0.182). The average value of the largest tumor diameter was 5.00±2.75cm in patients with AL and was 4.00±2.00cm in patients without AL(P=0.041).Conclusions Difference in gender, age, a history of diabetes, preoperative hypoproteinemia, laparoscopic assisted resection, with or without defunctioning stoma, the distance between distal margin and tumor edge, tumor's T stage and N stage had no significant correlation with the occurring of AL after Dixon operation for rectal cancer. The results was differernt from other researchers, which due to small sample size of AL in our research. However, we still find that AL is related to tumor's location, maximum diametre and M stage.