Meta-analysis Of Human Inflammatory Bowel Disease MicroRNA Expression Profiling Studies In Tissue

Background:Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory diseases.The pathogenesis of inflammatory bowel disease is complicate and unclear. Unique microRNAs (miRNAs) have been identified inflammatory bowel disease in recent studies which can be used to accurately diagnose the presence of inflammatory bowel disease and help predict disease recurrence. The common drawback of miRNA expression profiling studies is a lack of between-study agreement. These miRNAs likely show biological relevance to the inflammatory bowel disease, as opposed to sporadically reported miRNAs, which may be false positives. Purpose:WE integrated the results of different studies, in order to get a reliable result of differentially expressed miRNAs that related to inflammatory bowel disease. Methods:A meta-analysis was conducted to review the published microRNA expression profiling studies that compared the microRNAs expression profiles in inflammatory bowel disease tissues with those in normal bowel tissues. A logical solution is to determine the overlap among many miRNA profiling studies and to observe which differentially expressed miRNAs are consistently reported. A ranking system that considered the number of comparisons in agreement, total number of samples, and average fold change was used. This ranking system was also adopted in similar systematic reviews for other cancers. Results:According to the inclusion criteria and identification of duplicate publication, only 23 independent studies were included in the analysis.19 independent studies compared the inflammatory bowel disease tissues with normal tissues. There are 4 microRNA expression profiling studies comparing IBD-affected non-neoplastic tissue with IBD-cancer tissue. Four up-regulated microRNAs (miR-31?miR-146a?miR-223) a were consistently reported both in ulcerative colitis and crohn disease. In the studies that compare IBD-affected non-neoplastic tissue with IBD-cancer tissue, the most consistently microRNAs are two up-regulated microRNAs (miR-122?miR-146-5p). (Conclusions:The study identify several differentially expressed microRNA in inflammatory bowel disease. These mircoRNAs may have a greater potential clinical significance in the diagnosis, prognosis and treatment of inflammatory bowel disease.