| Objective:In order to discuss the effect of TangYiSheng NO.2 on the patients with impaired glucose tolerance and the effect on the Insulin and glucagon-like peptide 1 in diabetic rats, we mainly focus on two aspects of clinical observation and experimental study.Methods:1.Clinical study: 60 patients with impaired glucose tolerance were randomly divided into treatment group and control group, 30 cases in each group. The treatment group was treated with theTangYiSheng NO.2 combined with diet and exercise. Control group: diet and exercise therapy. The changes of TCM symptoms, blood glucose, blood lipid, body mass index and insulin resistance index were observed before and after treatment in two groups.2.Experimental study on the combined modeling method(high glucose and high fat diet and proper amount of intraperitoneal injection of STZ) to establish a model of diabetic rats, 6 weeks of drug intervention by enzyme linked immunosorbent assay method to observe the rat insulin and glucagon-like peptide 1 levels.Results:Clinical Results: TCM symptoms and signs of the treatment group was improved(P <0.05), and compared with the control group has the obvious advantages(P <0.01);The level of FPG,2hPG,HbA1 c,TC,TG and LDL-C in treatment group were significantly reduced,the two groups has differences(P <0.05), HDL-C after treatment were significantly different;Compared with the control group, the treatment group was significantly reduce BMI index(P <0.05).Experimental Results:Compared with the model group, TCM group and metformin, sitagliptin could reduce body weight and fasting plasma glucose(P <0.05), high dose group has a significant advantage(P <0.01);Compared with the model group,Sitagliptin and Chinese medicine group has obvious advantages(P <0.01) in the elevated fasting insulin respects and Medicines more effective than metformin and sitagliptin group(P <0.05);Compared with the model group, metformin, sitagliptin and Medicines insulin resistance index decreased significantly(P <0.01), but the Medicines has no significant difference with metformin and sitagliptin groups(P> 0.05);Compared with the model group,the level of serum GLP-1 in Metformin and sitagliptin groups have increased, but not statistically significant(P> 0.05), compared with the model group,the TCM group has significant difference(P <0.05).Conclusion:The symptoms of the patients with impaired glucose tolerance were significantly improved by the TangYiSheng NO.2, which could decrease the blood glucose and blood lipid, improve the insulin and resistance and elevate insulin and glucagon-like peptide 1 levels. |
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