| Background: Chronic HBV infection in China about 93 million people, including 20 million patients with chronic hepatitis B. A neonatal hepatitis B vaccination in China since 1992, hepatitis B infection rates have fallen sharply, but the onset of hepatitis B in China population base is big, poor rural medical conditions, it restricts the hepatitis B prevention and treatment work, therefore, effective prevention and treatment of hepatitis B remains a serious problem in China's medical and health care. Modern medical treatment of hepatitis B mainly interferon and nucleoside analogs antiviral(acid). But has its strict indications, clinical application and virological response, virus mutation and virological breakthrough. There are many different kinds of proprietary Chinese medicine, mainly of glycyrrhizic acid preparation, silymarin, such as drugs, but because of the lack of clinical dialectical accuracy and evidence of evidence-based medicine ? level, at present the chronic hepatitis B prevention guide(2015 edition), is no longer recommended. Chinese medicine as the treasure of the Chinese, long and long, has the advantage of independence road in disease treatment, in-depth excavation of the TCM treatment of chronic hepatitis B and methods, and explore the idea of combined Chinese and western medicine treatment, is that we will be the most important research of hepatitis B. Heels in recent years, many domestic and foreign literature reported in the prevention and cure of chronic hepatitis B, the application of traditional Chinese medicine syndrome differentiation combined antiviral drug treatment the curative effect is superior to use antiviral drugs, prevention and treatment of chronic hepatitis B opens up a new way of thinking for us.Objective: to observe the spleen qi and detoxification method that entecavir in the treatment of HBeAg negative chronic hepatitis B clinical curative effect, the exploration effective scheme combining traditional Chinese and western medicine treatment of HBeAg negative chronic hepatitis B.Method: 66 cases of clinic in affiliated hospital of shandong university of TCM liver disease outpatient HBeAg negative chronic hepatitis B patients, randomly divided into two groups, the experimental group and control group. Patients with spleen qi and detoxification method, traditional Chinese medicine compound liver soup combined entecavir rong; The control group use entecavir. Each for 96 weeks of clinical research, to observe the rate of liver function after often, abdominal ultrasound images to improve the situation, virology index and improve the syndromes.Results: 1. The experimental virus 0 cases, control group patients with virus in 1 case.2. Drug use 12 weeks and 24 weeks when no difference between the two groups of abdominal ultrasound images; At 48 weeks and 96 weeks, treatment group was better than the control group.3. The drug 12 weeks and 24 weeks, respectively at 48 weeks, experimental liver function after often rate were superior to control group, use rate of two groups of liver function after 96 weeks is often no obvious difference.4.12 weeks and 24 weeks of viral load to improve the situation and 24 weeks and 48 weeks HBsAg quantitative improvement experimental group is better than the control group.5. The improvement of clinical symptoms and signs, treatment group was better than the control group.Conclusion: using the method of invigorating blood detoxification joint entecavir in the treatment of HBeAg negative chronic hepatitis B, in improving the clinical symptoms and signs, improve liver inflammatory tissue damage, reduce HBV- DNA loads, such as lower HBsAg quantitative curative effect is superior to use entecavir. |
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