The Discussion About The Regularities Of Medication Of Professor Dezhi Cui In The Treatment Of Elderly Patients With Type 2 Diabetes And Its Common Blood Vessel Complications

Objective: With the use of data-mining to explore the regularities of traditional chinese medicine used by Professor Dezhi Cui in the treatment of elderly patients with type 2 diabetes and its common blood vessel complications, we attempted to sunmmerize and discuss Prof.Cui's thoughts in diagnosing and treating the diseases in order to provide new thoughts and methods for the diagnose and therapy of diabetes.Methods: With the four common blood vessel complications of elderly type 2 diabetes-- diabetes complicated with cerebral vascular disease, diabetes complicated with heart disease, diabetic nephropathy and diabetic foot as the breakthrough point, to regard the prescriptions of traditional Chinese medicine by Prof. Cui as the study object—394 formulas were collected in number of which there were 182,106,68,38 formulas respectively of aforesaid four common blood vessel complications— and by analysing frequency and association rules and using several other data mining methods, we digged out the central herbs, herb couples and herb groups of the formulas to explore the law of Prof. Dezhi Cui' s prescriptions in treating these dieases.Results: In the collected typical 182 formulas in the treatment of type 2 diabetes in elderly patients with cerebral vascular disease, tonic medicine were used most often,and secondly were promoting blood circulation to remove blood stasis medicine, antipyretic and flat liver wind medicine,and energen-invigorating drugs and activating blood analgesics are the most used in concrete function.The most used energen-invigorating herbs were baked licorice, astragalus, atractylodes and so on.The most used blood tonics were angelica sinensis and white peony root. Dwarf lilyturf tuber and barbary wolfberry fruit were often used as yin-nourishing herbs. Eucommia bark and desertliving cistanche were often used as yang-invigorating herbs.In the collected typical formulas of the treatment of type 2 diabetes in elderly patients with cerebral vascular disease, tonic medicine, promoting blood circulation to remove blood stasis medicine, antipyretic, flat liver wind medicine and expelling phlegm herbs were the most commonly used five herbs and combinations.Digestive formula,resolving superficies herbs, tranquillization herbs,and purgation herbs were also used often. Tall gastrodia tuber, kudzuvine root, sichuan lovage rhizome- earthworm, milkvetch rootChinese angelica, pinellia tuber- largehead atractylodes rhizome- tall gastrodia tuber and milkvetch root- peony root- earthworm- Chinese angelica were the representative herbs and combinations.In the prescriptions for elderly patients with type 2 diabetes mellitus complicated with heart disease, tonic medicine, antipyretic, promoting blood circulation and removing blood stasis herbs,herbs for regulating qi flow and expelling phlegm herbs were the most commonly used herbs and combinations,at the same time, digestive formula and tranquillization drugs were often accompanied with these herbs. Liquorice root, danshen root, snakegourd fruit, peach seed- safflower, spine date seed- Chinese arborvitae kernel, dwarf lilyturf tuber-Chinese magnoliavine fruit-heterophylly falsestarwort root,etc. were the representative herbs and combinations.In the prescriptions for elderly patients with type 2 diabetic nephropathy, tonic medicine, antipyretic, promoting blood circulation and removing blood stasis herbs and diuresis Shenshi medicine were the most commonly used herbs and combinations.Herbs could astring and consolidate channel for hemostasis were often accompanied. Prepared rehmannia root, cherokee rose fruit, oriental waterplantain rhizome, unprocessed rehmannia root- amur cork-tree, common yam rhizome- asiatic cornelian cherry fruit and dodder seed were the representative herbs and combinations.In the typical formulas for elderly patients with type 2 diabetic foot, antipyretic, promoting blood circulation to remove blood stasis medicine, tonic medicine and diuresis Shenshi medicine were the most commonly emploiyed herbs and combinations.Vines and insect herbs were broadly used in the treatment of this disease. milkvetch root- Chinese angelica, honeysuckle bud and flower, twotoothed achyranthes root, glabrous greenbrier rhizome- coix seed, earthworm- leech, suberect spatholobus stem- honeysuckle stemkadsura pepper stem- Chinese starjasmine stem were the representative herbs and combinations in this treament.Conclusion: Invigorating spleen-stomach and replenishing qi, moistening dryness method, nourishing kidney, promoting blood circulation for removing blood stasis were the main methods in the treatment of type 2 diabetes in elderly patients in all.Promoting blood circulation for removing blood stasis, eliminating dampness and diuresis, expelling remnant toxicity and eliminating phlegm and resolving turbidity methods were employed when excess syndrome was apparent,at the same time,invigorating spleen-stomach and replenishing qi,nourishing kidney,and moistening dryness method were accompanied in the treatment of essential pathogenesis. Prof.Cui took invigorating spleen-stomach and replenishing qi very important,and should be valued through treatment of the disease.We concluded a central formula by the result of the data-mining which was composed of double huang-- milkvetch root and golden thread, sijunzi decoction, shengmai powder. Milkvetch root, golden thread, common yam rhizome, tangshen, largehead atractylodes rhizome, indian bread, liquorice root, heterophylly falsestarwort root, dwarf lilyturf tuber, Chinese magnoliavine fruit, barbary wolfberry fruit, danshen root,fan baicao, kudzuvine root, lotus leaf, twotoothed achyranthes root, Chinese angelica were make up the central formula.The difference of pathological changes' target position,companied symptoms, condition of being insusceptible to a disease, cause of diseases should all be took account of,as well as the patient's condition critical or relatively gentle in the clinical treatment.Prof.Cui's formulas in the treatment mentioned above were abroudely used and the consequent were effective.The thoughts in diagnosing and treating are worthy to be referenced and practiced.To gain more marrow of Prof.Cui's thoughts in diagnosing and treating the elderly type 2 diabetes and its blood vessel complications,we should collect more formulas,dig more deeply about the regularities of the traditional chinese medicine and further sort out her clinical experience for the purpose of more widely application.