ERPs Study On Cognitive Function In Hypertension Of The Youth

Background With the incidence of hypertension is gradually getting younger and younger. Increased incidence of hypertension, and hypertension is an important risk factor for cerebral vascular disease. A large number of studies showed that cognitive dysfunction in elderly patients with hypertension. In recent years, some scholars believe that not only the elderly with high blood pressure can cause cognitive dysfunction, but also hypertension in youth will also cause specific cognitive function(attention and memory function) damage. Event related potential(ERPs) can capture milliseconds information reflect the cerebral cortex joint activities objectively, which is a non traumatic brain cognitive imaging technique. Event-related potentials(ERPs) used with less to assess cognitive function in young patients with hypertension. Event-related potentials(ERP) and cognitive impairment characteristic for studying the neural mechanisms of hypertension in younger patients.Now event related potential(ERPs) was mainly used to assess the changes in cognitive function caused by various diseases. Event related potentials(ERPs) was used to investigate the characteristics and neural mechanisms about the cognitive impairment in the young patients with hypertension. The youth cognitive impairment studied by the event related potentials,Experiment 1 Studing on event related potentials of visual non voluntary attention in young patients with essential hypertensionObjective To study the characteristics of visual attention in young patients with hypertension.Methods by mini mental state examination volume table of normal control group and primary cognition in young patients with hypertension were evaluated, through the event related potentials of advanced technology of cognitive evaluation, subjects as normal control were 23 cases and primary of young patients with hypertension of 24 cases.Results In young hypertensive group score is(25.92+1.25), mini mental state examination table score in normal control group is(29.00+0.74), compared with mini mental state examination volume subscale scores in hypertension group and normal control group mini mental state examination table were significantly higher(t=-10.36, P=0.01). Young hypertension group electrode in top location of the amplitude of P3 a was obvious decreased(P= 0.003,F=10.23). In the period of youth hypertension group,the P3 a latency was(362.27+7.03) ms, in the normal control group was(376.54+7.19) ms, and P3 a latency between the two groups was no significant difference(F=2.01, P = 0.16). The amplitude of N2 in hypertension and normal control group did not have significantly differences(F=0.12, P=0.73); This study found no significant positive correlation between event related potentials related the composition of P3 a amplitude and mini mental mental state examination table score(r = 0.19, P = 0.21).Conclusions The process of processing of nonvoluntary attention has been caused damage of young people's primary hypertension.The adolescent hypertension caused visual involuntary attention impairment. The component of event related potentials of P3 a can be early used to value the visual involuntary attention objectively in adolescent hypertensive patients.Experiment 2 Studing on event related potentials of visual nonvoluntary attention in the youth with essential hypertensionObjective Impact of the young hypertensive on the event related potential P3 b.Methods Using P3 b component of the event related potentials(ERP) to value visual voluntary attention of 24 essential adolescent hypertensives and 23 normotensives.Results Evoked stimulus by target in youth hypertension group, P3 b amplitude was [(4.09 0.59) ?V], and in the normal control group P3 b amplitude was [(6.10±0.59) ?V], the difference between the two groups has statistical significance(F=4.73, P < 0.05), and the young hypertension group decreased significantly. The top location area decreased most obviously(P < 0.05). P3 b latency in the youth hypertension group is(391.34±6.13ms), P3 b latency in normal control group(401.31±6.27ms), but between the two groups the difference has no significance(F=1.29,P > 0.05). MMSE scores and P3 b have significantly positive correlation(r = 0.61, P < 0.05).Conclusion Youth hypertension patient's voluntary attention ability has been damaged; In the adolescent, P3 b for early identification and intervention cognitive dysfunction was a very important clinical significance.