| Background Migraine is a common neurovascular headache.It is characterized by moderate to severe throbbing pain with sensitivity or intolerance to light and sound during the headache and is often accompanied by nausea and vomiting.It can be aggravated in daily activities.According to a epidemiological study,the annual prevalence of migraine in our country is 9.3% with a ratio of 1: 2.09.Migraines without aura account for about 80% of all migraines and have a serious impact on the patients' daily life.Event related potentials(ERPs)can reflect the change of brain potential caused by a certain psychological activity.It is a window to observe the process of brain activity and is related to the cognitive process such as signal perception,attention,discrimination analysis,working memory.ERPs with millisecond resolution can reflect the activity of the cerebral cortex,especially in the assessment of cognitive function and cortex information processing.It is a noninvasive brain cognitive imaging technology.With the deep study of migraine,more and more attention has been paid to the cognitive function of migraine.Previous studies have been shown that migraine attacks can lead to vasospasm,so it can increase the risk of vascular events and the incidence of clinical white matter lesions without clinical symptoms.The cognitive function of the migraine patients is impaired in attacking period,but it is not clear in interictal period.In this study,the characteristics and neural mechanisms of cognitive dysfunction in the interictal period of migraine without aura were studied by using ERPs.Experiment 1 Effects of migraine without aura on visual involuntary attention: an event-related potentials studyObjective To explore the effect of migraine without aura on visual involuntary attention using ERPs.Methods The visual Oddball paradigm was used to examine the event-related potential (ERPs)P3a components of 26 migraineurs without aura(migraine group)and 26 normal controls(control group),and the subjects were submitted to cognitive assessment by Montreal Evaluation(Mo CA)scale.Results MoCA scores of migraine group was significantly lower than control group(P<0.05).There was no significant difference in the amplitude of N2 between migraine group and control group(P> 0.05),but the latency of N2 in frontal area was significantly shorter than control group(P <0.05).The amplitude of P3 a in migraine group was significantly lower than control group(P <0.05),and the frontal area was the most significant(P = 0.007).The latency of P3 a in both groups were no statistical significance(P> 0.05).There was a negative correlation between pain scores and P3 a amplitude(P <0.05).Conclusions The frontal area of migraine patients without aura has higher awareness and preparedness for unexpected events,but the processing capacity declines,the effective resources in information processing decreases,and the frontal area has dysfunction.The change of P3 a provides a new objective evidence for the processing of involuntary attention impairment in migraine without aura.Experiment 2 Effects of migraine without aura on visual voluntary attention: an event related potential studyObjective To explore the effect of migraine without aura on visual voluntary attention..Methods The visual Oddball paradigm was used to examine the event-related potential(ERPs)P3b components of 26 migraineurs without aura(migraine group)and 26 normal controls(control group),and the subjects were submitted to cognitive assessment by Montreal Evaluation(Mo CA)scale.Results Mo CA scores of migraine group was significantly lower than control group(P<0.05).The mean amplitude of P3 b in the migraine group was significantly lower than control group(F = 13.18,P = 0.00),and the amplitude of PZ size was significantly lower than control group(F = 19.54,P = 0.00).The mean latency of P3 b in the migraine group was longer than control group,but there was no statistically significance(F = 0.60,P = 0.45).The amplitude of visual P3 b was positively correlated with Mo CA scores(r = 0.47,P = 0.03), but it was no significantly correlated with frequency,duration,history and pain scores of migraine attack(P> 0.05).Conclusion The cognitive processing content of migraine changes,and visual voluntary attention declines.It indicates that migraineurs have mild cognitive dysfunction.Visual P3 b was not significantly associated with migraine frequency,duration,duration,and pain scores,suggesting that voluntary attention deficit may be a general feature of migraineurs without aura.. |
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