Correlation Between Dynamic Contrast Enhancement Mri And Angiogenesis In Different Molecular Subtypes Of Breast Cancer

PurposeTo explore the correlation between tumor angiogenesis with microvessel density(MVD)and vascular endothelial growth factor(VEGF) angiogenesis and semi-quantitative parameters of dynamic contrastenhanced MRI(DCE-MRI) with early-phase enhancement rate(E1), maximum linear slope rate(Sl OPE), and time to peak enhancement(TTP)in breast cancer subtype.Materials and MethodsThis retrospective study included 103 patients with breast cancer verified by histology.DCE-MRI was performed preoperatively for all patients within aweek and DCE parameters were recorded for correlative analysis. Immunohistochemical exams were performed to categorize four tumor subgroups and to determine the angiogenesis expression with MVD and VEGF. Correlations were analyzed between the DCE parameters and angiogenesis expression in different subtypes.ResultsThere were no significant different in DCE parameters between breast cancer subtypes.The MVD count of triple-negative subtype was significantly higher than Luminal B subtypes(P=0.02). The VEGF expression level had significant difference between breast cancer subtypes except between Luminal A and Luminal B. There were positively correlation between MVD and EER and SLOPE(r=0.55,P=0.015 and r=0.859, P<0.001), and negatively correlation between MVD and TTP(r=-0.60, P=0.007)in Triple-negative subtype. The MVD of Luminal A subtype was positively correlated with EER and SLOPE(r=0.71,P<0.001 and r=0.51, P=0.001). The MVD of Luminal B subtype was positively correlated with EER and SLOPE(r=0.38,P=0.016 and r=0.39, P=0.023).ConclusionTriple-negative subtype was more abundant angiogenesis than Luminal B subtype. The MVD of Luminal and Triple-negative subtypes were correlated with E1 and SLOPE.