The Correlation Of 25-hydroxy VitaminD₃ And Insulin Resistance With Papillary Thyroid Carcinoma

Object:This study aims to investigate the correlation of 25-hydroxyvitamin D₃ and insulin resistance with papillary thyroid carcinoma. Method:Randomly select 358 patients diagnosised with PTC during 2014.9-2015.9 in the First Affiliated Hospital of Zhengzhou university as observation group.The control group consists of 290 healthy volunteers. Detect the 25-hydoxy vitamin D₃?fasting blood glucose?fasting insulin of all the members and explore the relationship between 25-hydroxyvitamin D₃?insulin resistance and expression of BRAFV600 E ?lymph node metastasis in PTC. Results:?1? Comparison between PTC and the normal control group:the 25-hydoxy vitamin D₃ concentration in PTC?15.8±5.00??ng/ml?was significantly lower?P=0.000?than the control?19.1±5.66??ng/ml?; the IRI in PTC?1.03±0.220?was significantly higher?P=0.000?than the control?0.965±0.187?;?2? Comparison between PTC with and without lymph node metastasis: the 25-hydoxy vitamin D₃ concentration in PTC with lymph node metastasis?13.3±4.68??ng/ml?was significantly lower?P=0.000?than the PTC without lymph node metastasis?16.7±4.82??ng/ml?; the IRI in PTC with lymph node metastasis?1.18±0.191?was significantly higher?P=0.000?than the PTC without lymph node metastasis?0.985±0.207?; the age in PTC with lymph node metastasis?40.4±13.0?was significantly lower?P=0.002?than the PTC without lymph node metastasis?45.2±11.1?.?3? Comparison between PTC with and without BRAF genetic mutation: the 25-hydoxy vitamin D₃ concentration in PTC with BRAF genetic mutation?15.3±4.91??ng/ml?was significantly lower?P=0.000?than the PTC without BRAF genetic mutation?18.6±4.52??ng/ml?; the IRI in PTC with BRAF genetic mutation?1.08±0.196?was significantly higher?P=0.000?than the PTC without BRAF genetic mutation?0.809±0.199?; there was no significant difference between two groups of age.?4? Binary logistic regression analysis showed insulin resistance and female were risk factors of PTC,while 25-hydoxy vitamin D₃ was protective factor. Conclusion:25-hydoxy vitamin D₃ may be a protective factor for PTC. Improving the insulin sensitivity may help prevent the occurrence and development of PTC.