| Objective:To investigate the possibility and the extent of insulin resistance in infants and neonates perioperatively,and evaluate the effect of the intervention study influncing the insulin resistance.Methods:Forty infants undergoing elective surgery were collected and divided into control group and test group randomly.There were 25 cases and 15 cases in the control group and test group respectively. During preoperative overnight fasting,the control group were given no infusion while the test group were given 5 milligrams per kilogram per minute of glucose until 2 or 3 hours before the anesthesia induction .The operation all began from 8:30AM to 9:00AM and lasted from 15 minutes to 135 minutes.Based on the degree of operative stress,the control group were divided into the mild , moderate and severe sub-groups.The serum concentration of insulin and glucose were detected before operation and the first day postoperatively,and the insulin sensitivity were calculated by the formula : insulin sensitivity = 1/(FINS×FPG).The results were analyzed with the spss13.0Results: Preoperatively and postoperatively ,the levels of insulin sensitivity were significantly different in the two groups (P<0.05) . Nostatistical difference were found in the basal levels of insulin sensitivity preoperatively while significantly different in statistics ( P<0.05 ) postoperatively between the two groups . The levels of insulin sensitivity were no statistical difference among the subgroups in the control group(P>0.05) .Conclusion:The insulin resistance was found after elective operation in infants.lt seemed the extent of insulin resistance was not associated with the degree of operation stress .It's possible to reduce the extent of insulin resistance by giving glucose load.
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