| Objective: This paper is aim to observe the efficacy of Traditional Chinese Medicine and study its influence on Related clinical laboratory indexes of patients who have chronic kidney diseasee of level 3-5 and qi of spleen and kidney deficiency with damp turbidity and blood stasis,then to discuss its possible mechanism on the relief of symptoms and delaying the progression of renal failure as well as improving renal function.Method: 1.60 patients in Chinese Medicine Hospital of Hubei Province are chosen on this study. These patients all meet the standard of chronic kidney disease of level 3-5 and are diagnosed as the chronic kidney disease with qi of spleen and kidney deficiency with damp turbidity and blood stasis. They are divided into two groups randomly, with 30 patients in each group. The two groups of patients were treated with the integration of Western medicine treatment, in addition, the treatment group plus the traditional Chinese medicine treatment. Two groups were treated with 8W after the observation and comparison of clinical symptoms and symptoms of traditional Chinese medicine and related laboratory indicators. Each dose of medicine 400 ml water immersion, were decocted twice, first boil, small fire boiling for 30 minutes, second with 200 ml of water to boil and fry for 20 minutes, is to decoct medicine juice 300 ml, in early dinner taking 150 ml, 2 weeks for a course of treatment were treated for 2 courses. Observation index:(1) biochemical detection: the two groups of patients before treatment and at the end of each course of treatment related biochemical indicators: Analysis of renal function index, serum creatinine(Scr), blood urea nitrogen(BUN), blood uric acid and serum cystatin-C(Cys C); Hemoglobin(HGB), red blood cell(RBC), albumin(ALB) levels; Calcium, phosphorus and parathyroid hormone(PTH) levels.(2) the change of symptom scores of two groups before and after treatment.(3) the patients were followed up to observe the changes of clinical symptoms, signs, adverse reactions and side effects of drugs.(4) statistical analysis: all data use medical statistical software SPSS22.0 statistical analysis and experimental data said group compared with paired t test, were compared between groups using independent sample t test; technical data using chi square test. P < 0.05 for a statistically significant difference; P < 0.01 indicated that there was a significant statistical difference; P > 0.05 indicated that there was no statistical significance.result: Before and after the treatment two groups cases clinical symptom integral value comparison: two groups of patients after treatment of clinical symptom score values were decreased, before and after treatment compared with significant difference(P < 0.05). After treatment, the treatment group TCM clinical symptom score values compared to the control group improved significantly(P < 0.05) Two before and after treatment, the total effective rate of the 2 groups were compared: the total effective rate of treatment group was 73.3%, and the total effective rate was 56.7%. The total curative effect of the two groups was significantly different(P < 0.05).3. Before and after treatment, two groups of patients renal function indexes(SCR, BUN,UC, Cys C): two groups of patients after treatment of SCR, bun, UC, Cys C value were improved compared with before treatment(P < 0.05). After the treatment, the treatment group and control group: SCR, bun, UC, Cys C value compared with a significant difference(P < 0.05); 4.The comparison of the two cases of hemoglobin(HGB), red blood cell(RBC), serum white white(ALB) index before and after the treatment, the two groups of patients before treatment and after, there was no statistically significant difference(P < 0.05); after treatment, treatment group and control group, each value is no significant statistical difference(P < 0.05); 5. The comparison of the two groups of cases of serum calcium, phosphorus and parathyroid hormone(PTH) index before and after the treatment, the treatment group before and after treatment of serum calcium and PTH value comparison, the difference was statistically significant(P < 0.05); treatment group before and after treatment of serum phosphorus level, had no statistical significance(P > 0.05); the control group before and after treatment with calcium, phosphorus and PTH values, there was no statistical significance(P > 0.05); after treatment, the treatment group and control group, the difference of calcium and phosphorus had statistical significance(P < 0.05) PTH values no statistical significance(P > 0.05). 6. Two groups of patients in the treatment process and the subsequent month of follow-up no obvious adverse reaction occurred.conclusion Through clinical research, preliminary evidence of Traditional Chinese Medicine in the treatment of chronic kidney disease(meet the standard of chronic kidney disease of level 3-5), markers of renal function and card is the "Qi deficiency of spleen and kidney, blood stasis turbid stasis type) is a certain clinical value, can reduce the clinical symptom score, improve the SCR, BUN, UA, Cys C, elevated hemoglobin(HGB) and red blood cell(RBC), stable calcium, phosphorus and parathyroid hormone(PTH) level, for traditional Chinese medicine in the treatment of chronic kidney disease(CKD) provides a new way of thinking. |
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