The Clinical Observation Of Yinhuo Butu Method And Ursodeoxycholic Acid Capsule For Primary Biliary Cirrhosis

Objective: To watch the clinical curative effect and security of the primary biliary cirrhosis(PBC) by using Yinhuo Butu Method with ursodeoxycholic acid capsule, and to explore the essence of TCM syndrome of the disease, to reveal the mechanism of Yinhuo Butu Method, to provide new ideas and methods for the clinical treatment of PBC.Methods: Adopting the method randomized controlled clinical trial in May 2013 to October 2015 in Hu Bei province hospital liver disease outpatient and the inpatient treatment of primary biliary cirrhosis(syndrome of traditional Chinese medicine " liver kidney deficiency, fire not worm soil type") patients were randomly divided into two groups: Yinhuo Butu Method with UDCA therapy group, UDCA a control method and incorporated into the statistical analysis of a total of 50 cases.Observed in the two groups after 1, 3 months of therapy liver function index, total score of syndromes of traditional Chinese medicine(TCM), the change of clinical symptoms and signs scores, compare two groups of clinical curative effect.Results:1 Overall curative effect comparison: 1 month after treatment, the treatment group and control group total effective rate 57.69%, 50.00% respectively, no significant difference after statistics processing(P > 0.05);3 months after treatment, treatment group total effectiveness 80.77%, control group total effective rate was 62.50%, the treatment group compared with control group with significant difference(P < 0.05). 2 TCM syndrome total integral comparison: 1 month after treatment, the treatment group patients with TCM syndrome total score(7.12 � 2.11) before the treatment(10.32 � 5.56) have improved,with significant differenc(P < 0.05), while the control group before and after treatment of TCM syndrome total integral without decreased,with no significant differenc(P > 0.05).3 months after treatment, the treatment group of TCM syndrome total score was 2.16�0.11, lower than before treatment,with significant differenc(P < 0.05);The control group after treatment of TCM syndrome total score was 5.42�1.18, lower than before treatment,with significant differenc(P < 0.05);After treatment of TCM syndrome total score in treatment group than the control group decreased,,with significant differenc(P < 0.05). 3 Syndromes quantitative score comparison: 1 month after treatment, the treatment group patients side rib dull pain, lumbar debility, jaundice, dry throat, dry mouth, bone steaming hot flashes, insomnia, much dream, lower extremity edema, diarrhea stool of TCM syndrome score than before treatment decreased,with significant differenc(P < 0.05), while the control group only side rib ache, jaundice, lower limb edema and other syndromes quantitative score before the treatment decreased, with significant differenc(P < 0.05), and the treatment group patients with lumbar debility, jaundice, dry throat, dry mouth, bone steaming hot flashes, insomnia, much dream, lower extremity edema, diarrhea stool syndromes quantitative score lower than the control group, with significant differenc(P < 0.05);3 months after treatment, the treatment group the quantification of syndromes are lower than before treatment,with significant differenc(P < 0.05), whereas the control bone steaming hot flashes, oral ulcer, insomnia, much dream, defecate diarrhea and other syndromes quantitative score no decrease than before treatment,with no significant differenc(P > 0.05), and the treatment group patients with bone steaming hot flashes, insomnia, much dream, oral ulcer, defecate diarrhea and other syndromes quantitative score lower than the control group,with significant differenc(P < 0.05). 4 Liver function index comparison: 1 month after treatment, the treatment group ALT, AST and liver function index lower than the control group,with significant differenc(P < 0.05).3 months after treatment liver function index before the treatment two group were lower,with significant differenc(P < 0.05), and the treatment group(ALP, GGT, TBi L and liver function index down compared with control group,with significant differenc(P < 0.05). 5 Safety observation: the treatment group and control group before and after treatment the blood, urine, excrement and urine routine, renal function, electrocardiogram observation indexes such as no abnormal change.Conclusions: Yinhuo Butu Method with UDCA therapy PBC is pure western medicine treatment method has better curative effect, in eliminate or relieve the clinical symptoms, improve liver function showed a clear advantage. "Liver Kidney deficiency, fire not warm soil" is the important pathogenesis of PBC, using Yinhuo Butu Method for guiding clinical treatment of PBC is safe and effective method, is worth further clinical research.