USH Test For Cervical Intraepithelial Neoplasia And Cervical Cancer Screening Evaluation Research

Objective:Evaluate the clinical application value of urine sulfhydryl compounds test(USH)for cervical intraepithelial neoplasm and cervical cancer screening.Method:These test were used in 360 women,aged from 21 years to 72 years,visited to Beijing military region general hospital from 1st November 2013 to January 31,2015.Check these women in cervical thinprep cytologic test(TCT),DNA quantitative analysis,cervical human papilloma virus DNA testing(HPV)and USH.And the women whose TCT,HPV and DNA quantitative analysis was abnormal under vaginal endoscopy and biopsy pathology.Patients with operation indications for surgery.Divided those women into three groups:Group I-normal control group:120 people,Group II-cervical lesion group:121people,Group III-other tumor group:A total of 119 people.Testing results of three groups entry to SPSS software for statistical analysis and comparison,understood the degree of sensitivity,specificity,positive predictive value,negative predictive value,the misdiagnosis rate,missed diagnosisrate,positive likelihood ratio and negative likelihood ratio,Kappa value.Take clinical diagnosis as the gold standard,Evaluate clinical significance of TCT,DNA quantitative Analysis,human papillomavirus DNA for diagnosing cervical intraepithelial neoplasia and cervical cancer.Evaluate clinical significance of USH for cervical intraepithelial neoplasia and cervical cancer screening.Results:(1)The positive rates of USH test in normal control group women,cervical lesion group women and other tumor group women are 20.00%,84.30%,12.61%.In cervical lesion group,the positive rates of USH test in CINI group,CINII group,CINIII group and cervical cancer group,respectively were 77.14%,86.36%,89.74%,84.00%.Take the gold standard of clinical diagnosis:USH test screening of cervical cancer and cervical intraepithelial neoplasia's sensitivity,specificity,the total coincidence rate positive predictive value,negative predictive value,the misdiagnosis rate,missed diagnosis rate,positive likelihood ratio,negative likelihood ratio and Kappa consistency test results respectively84.30%,83.68%,83.89%,72.34%,91.32%,16.32%,15.70%,5.17,0.19 and 0.6531.(2)The positive rates of TCT in normal control group women,cervical lesion group women and other tumor group women are 14.17%,90.91%,0.84%.The positive rate of cervical cells DNA quantitative analysis in the normal control group,the cervical lesion group,the other tumor group were 19.17%,74.38%,4.20%.HPV in the normal control group,the cervical lesion group,the other tumor group,the positive rates were30.00%,59.50% and 5.04% respectively.In cervical lesion group,The positive rate of TCT in CINI group,CINII,CINIII group,cervical cancer group respectively were 82.86%,81.82%,97.44%,100.00%.the positive rate of cervical cells DNA quantitative analysis of CINI group,CINII group,CINIII group,cervical cancer group were 68.57%,77.27%,71.79% and 84.00% respectively.the positive rate of HPV in CINI group,CINII group,CINIII group,cervical cancer group were 60.00%,54.55%,58.97% and 64.00% respectively.(3)Take clinical diagnosis as the gold standard,TCT for cervical cancer and cervical intraepithelial neoplasia,sensitivity,specificity,the total coincidence rate sensitivity,positive predictive value,negative predictive value,the misdiagnosis rate,missed diagnosis rate,positive likelihood ratio,negative likelihood ratio and Kappa consistency test results respectively were 90.91%,92.47%,91.94%,85.94%,95.26%,7.53%,9.09%,12.07,0.10 and 0.8220.Take clinical diagnosisas as the gold standard,DNA quantitative analysis for cervical cancer and cervical intraepithelial neoplasia specific degree,sensitivity,specificity,the total coincidence rate sensitivity,positive predictive value,negative predictive value,the misdiagnosis rate,missed diagnosis rate,positive likelihood ratio,negative likelihood ratio and Kappa consistency test results respectively were 74.38%,88.28%,83.61%,76.27%,87.19%,11.72%,25.62%,6.35,0.29 and 0.6305.Take clinical diagnosis as the golden standard,cervical human papilloma virus(HPV)DNA for cervical cancer and cervical intraepithelial neoplasia,sensitivity,specificity,the total coincidence rate positive predictive value,negative predictive value,the misdiagnosis rate,missed diagnosis rate,positive likelihood ratio,negative likelihood ratio and Kappa consistency test results respectively were59.50%,82.43%,74.72%,63.16%,80.08%,17.57%,40.50%,3.39,0.49 and 0.4254.(4)USH and TCT,cervical cell DNA quantitative analysis part inconsistent results in the difference of three methods was no statistically significant.Conclusion: In this study USH screening of cervical cancer,cervical intraepithelial neoplasia has good sensitivity,specificity and Kappa consistency inspection results.Comparising with common cervical cancer and cervical intraepithelial neoplasia screening methods TCT,HPV and cervical cell DNA quantitative analysis,have roughly the same the total coincidence rate,the difference was not statistically significant.Compared with other screening method of cervical cancer and cervical intraepithelial neoplasia,USH operate more simply,obtained test results Faster,do not need special equipment and cost low.