Association Of Hepatitis B Virus Surface Antibody Positivity With The Presence Of Metabolic Syndrome

Background and Perspectives: incidence of the Metabolic syndrome(metabolic syndrome,MS)rises up seriously in China.Hepatitis B HBV(Hepatitis b virus,HBV)turns to be a trend of epidemic pandemic virus in the country due to the high population density and large population base number.In order to prevent HBV infection increase much further epidemic in our country,hepatitis b vaccination is considered as a low-cost and most effective methods of prevention and treatment.Metabolic syndrome and hepatitis B infection plays ongoing effects on human health which people is lethal of it.Thus,an exploration of hepatitis b surface antibody positive correlation between metabolic syndrome and research is essential.Experimental Methods: the object of study is a tertiary hospital in the North 2014 which has 2,274 participations attended the physical examination.We analysis on the age,medical history(diabetes,hypertension,cancer,severe kidney disease,etc.)collection;height,weight,blood pressure(systolic / diastolic)measurements;fasting blood glucose,cholesterol,triglycerides,low-density lipoprotein,high density lipoproteins,urea,creatinine,aspartate aminotransferase,alanine aminotransferase,hepatitis B surface antigen(HBsAg),hepatitis B surface antibody(HBsAb),hepatitis B e antigen(HBe Ag),hepatitis B e antibody(HBeAb),hepatitis B core antibody(HBc Ab)measurement.By using SPSS23.0 statistical software,Measurement data arerepresented by mean ±and standard deviation(x±S)),Count dataare represented with the composition ratio or rate.The Normal distributed databetween the two groups aere compared by using a group t test.Rates were compared using chi-square test.Metabolic syndrome and its components in risk with age,sex,hepatitis B surface antibody positive status was analyzed by binary linear regression analysis,P <0.05 was statistically significant.Results: this study analyzes participation in 2014 a Northern healthy hospital staff,2274 cases under its HBsAb positive and negative States into the experimental group and the control group.The analysis and contrast between the two groups for the Age,anthropometric measurements(height,weight,body mass index BMI,systolic bloodpressure SBP / DBP DBP),liver biochemical(alanine aminotransferase ALT,aspartate aminotransferase AST),renal function(blood urea nitrogen BUN,creatinine CREA),metabolic parameters(cholesterol: make the difference between the mean cholesterol TC,triglyceride TG,high density lipoprotein HDL-C,LDL LDC-L,fasting plasma glucose FPG)shows that : comparison of average level for Age,and ALT,BUN,SBP,TG between HBsAb(+)group and HBsAb(-)groups are analysised,the difference was statistically significant(p<0.05),in the meantime HBsAb(+)are lower than HBsAb(-)group on each average levels.The ratio analysis of female / male ratio difference between the two groups has not statistically significant(P> 0.05).However hypertension HTN,hypertriglyceridemia are part of the metabolic syndrome and hypertriglyceridemia are important outstanding performance of abdominal obesity,insulin resistance.And abdominal obesity,insulin resistance is often earlier than the onset of type 2 diabetes.And abdominal obesity,insulin resistance,often early in the onset of type 2 diabetes.Through the prevalence of metabolic syndrome and its components risk with age,gender,HBsAb(+)between rows of binary Logistic regression analysis,we find that Age risk for metabolic syndrome is a relatively independent risk factors,,the older age people,the higher the risk of developing metabolic syndrome happen.And then women and HBsAb(+)for risk of metabolic syndrome in the 95% of the confidence interval is a protective factor,especially in female subjects HBsAb(+)the individual's risk of developing MS 35.9%.The components of MS(BMI?25kg / m2,HTN,TG?1.70mmol/ l,HDL-L <1.04 mmol / l,FPG?6.1mmol / l)of risk with age,gender,HBsAb(+)binary Logistic regression results:For obese(BMI?25kg / m2),high blood pressure(Bp?130 / 85 mmHg or a history of HTN),glucose(FPG?6.1mmol / l or a history of DM),hypertriglyceridemia(TG?1.70 mmol / l)Age is an independent risk factor for the age and low high-density lipoprotein hyperlipidemia(HDL-L <1.04 mmol / l)the risk was not statistically significant(P> 0.05%).For Women,however,the HBsAb(+)with hepatitis B surface antibody positive status are protective factors for obesity,hypertriglyceridemia,hypertension,low high-density lipoprotein hyperlipidemia;HbsAb in female subjects(+)individuals reduce the risk of obesity 52% reduction in the risk of HTN 38.3%,suffering from hypertriglyceridemia(TG?1.70 mmol / l)56.1%risk reduction.While,analysis In male subjects did not see the above,the difference was not statistically significant(P> 0.05).At last,we find the result as per the chi-square test of MS and the prevalence of each component in HBsAb(+)that : For male patients,MS and the prevalence of each component in the HBsAb(+),HBsAb(-)difference between the two groups was not statistically significant(P> 0.05);For female patients,MS and its components in the prevalence of HBsAb(+)group,HBsAb(-)difference between the groups were statistically significant(P <0.05): HBsAb(+)group of MS prevalence was 7.2%;HBsAb group MS prevalence was 13.1%;HBsAb(+)group FPG?6.1mmol / l prevalence rate of 6.8%;HBsAb(-)group FPG?6.1mmol / l prevalence was 11.8%;HBsAb(+)group BMI?25kg / m2 prevalence rate of 20.2%;HBsAb(-)group BMI?25kg / m2 prevalence rate of 31.3%;HBsAb(+)group HTN prevalence was 29.6%;HBsAb(-)group HTN prevalence rate was 38.4%;HBsAb(+)group TG?1.70 mmol / l prevalence of 9.2%;HBsAb(-)group TG?1.70 mmol / l prevalence rate of 16.2%;HBsAb(+)group HDL-L <1.04 mmol / l prevalence rate of 8.0%;HBsAb(-)group HDL-L <1.04 mmol / l prevalence rate of 10.8%.Thus,in women,the prevalence of the metabolic syndrome and its various components,HBsAb(+)individuals are less than HBsAb(-)individuals.Conclusion: Human age for MS and each component of metabolic syndrome is a relatively independent risk factors.The older age,the higher the risk of MS gets.The gender of female with HBsAb(+)at risk for MS and all components are protective factors,In Summary,HBsAb(+)state in an individual may reduce the risk of MS and the prevalence of MS.