The Synthesis And 3D Printing Assisted Applications Of ZnO,Ag Based Nanosized Antibiotics

According to actual requirements from different patients, three- dimensional(3D) printing can construct precise bio-mimetic structure, which conform to the development trend of biological medical products in the future, namely rapid preparation progress, customized function and precise morphology. However, even though 3D printing devices show specific advantages on morphology control and mechanical properties, there still exist some problems in terms of specific clinical application, such as limited printed materials, lacking surface properties and so on. The technology solutions, which can rapidly, safely and effectively improve the surface performances of 3D printing products, are urgently needed. Based on the aforesaid conditions, this thesis put forward the solution which combines curved surface nano modification and 3D printing, through loading functional nanomaterials Zn O, Ag on the surface of 3D printing device, significantly improving the antimicrobial properties, biocompatibility, mechanical properties, drug release characteristics and other key performance parameters of the final products. As the application examples, this thesis focuses on the 3D printing customized deep sleep earplugs and 3D printing antibacterial orthopedic implants.In the first part, for the first time, homogeneous and well-ordered functional nanoarrays were grown densely on the complex structured three dimensional(3D) printing frameworks through a general plasma enhanced atomic layer deposition(PEALD) assisted hydrothermal surface engineering process. The earplugs show superior sound insulation characteristic, comfortable wear experience, good abrasion resistance, surface antibacterial properties and biocompatibility. In addition, ZnO nanoarrays loaded on the surface of clinical bone nail can effectively kill bacteria, preventing the postoperative infection.In the second part, we proposed the solution that constructed a layer of antibacterial film on the surface of 3D printing implant through film forming agent Polyvinyl Alcohol(PVA) and polyacrylic acid(PAA), mixing with small sized Ag nanoparticles. Average size of the Ag nanoparticles was less than 10 nm, showing powerful antibacterial properties. What's more, through changing the concentration of silver nanoparticles as well as film forming agent proportion of PVA and PAA, drug loadings and the drug release rate could easily be controlled according to actual needs, achieving the goal of precise treatment. Animal experiments demonstrated that the implant system showed better anti-infection performance, which was expected to be applied in the treatment of clinical open fractures.