Research On The Technology And Performance Of Tissue Engineering Stent Based On 3D Printing

Tissue engineering is an emerging discipline involving life sciences, engineering and materials science and other many fields.As a carrier for tissue engineering, tissue engineering scaffold provides a metabolic environment for cell growth and determines the size and shape of regenerated tissue and organs, which has become a hot topic in the field of tissue engineering. It is well know that traditional methods have been widely used for preparing tissue engineering scaffold, which may lead to some problem, such as poor controllability of porosity, low penetration of scaffold holes, holes uneven distribution, etc. The three-dimensional printing technology as a new method for preparing tissue engineering scaffold, can realize any structure and personalized scaffold preparation with the benefits of avoiding the existing problems in the traditional preparation methods. It has great prospects in the preparation of tissue engineering scaffold.Firstly, this thesis introduces some methods including the tissue engineering scaffold traditional preparation methods and new preparation methods based on the rapid prototyping technology. On the basis of the performance requirements analysis of tissue engineering scaffold, this thesis identifies the spray droplets based on piezoelectricity and light curing under a pneumatic control to achieve rapid prototyping for tissue engineering scaffold.Secondly, according to the basic principle of piezoelectric spray droplets and light curing, we choose a suitable forming material and design a reasonable experimental program to determine the process parameters and material composition. Then, we analyze the impact of various parameters on scaffold forming conditions and successfully prepare a complete structure of tissue engineering scaffold. Finally, the experiment for testing the performance of the scaffold including microstructure, porosity, water absorption and degradation. Test results show that piezoelectric spray droplets and pneumatic light curing technology has prepared tissue engineering scaffolds with a high porosity, high water absorption and good biocompatibility.This thesis has a certain value for tissue engineering applications which lays foudations for the further research of tissue repair, reconstruction, regeneration.