| Objective:To observe the clinical effect of testosterone individualized therapy in patients with different level of serum testosterone.Methods:68 patients of late-onset hypogonadism(LOH) were selected in our hospital from January 2015 to June 2015 in this clinical research. Based on different level of serum testosterone, these LOH patients were taken into 2 groups as Absolute Reduction group(AR group) and Relative Reduction group(RR group). The level of serum testosterone was lower than 8 nmol/L in AR group(contained 43 patients)while the level of serum testosterone was 8~11.5nmol/L in RR group(contained 25patients). AR group underwent Eleven acid testosterone 80 mg each time, 2times per day. The patients in RR group were divided into two subgroups as RR group A(contained 12 patients) and RR group B(contained 13 patients) randomly. RR group A also underwent Eleven acid testosterone 80 mg each time, 2times per day. And RR group B underwent small dose of Eleven acid testosterone, 40 mg each time, 2times per day. All patients were treated 3 months. The scores of ADAM, levels of sex hormones and adverse reaction were recorded to evaluate the clinical effect.Results:(1)The Physical fitness score, Psychological score and Sexual function score in AR group, RR group A and RR group B all were improved compared to pre-treatment(P<0.05). 3 months later, the comparison of ADAM score between RR group A and RR group B had no obvious differences(P>0.05).(2) The level of TT were increased and the level of SHGB were decreased compared to pre-treatment in AR group, RR group A and RR group B(P<0.05). 3months later, the level of TT in RR group A and RR group B were both exceeded 12nmol/L, and the level of TT in RR group A were higher than RR group B(P<0.05).The comparison of SHBG between RR group A and RR group B had no obvious differences(P>0.05).(3)There were no severe adverse reaction happened during treatment. And the incidence of hematocrit elevation and PSA elevation in RR group B were lower than RR group A(P<0.05).Conclusion:The LOH patients whose serum testosterone was lower than 8 nmol/L should underwent regular dose of testosterone therapy while the LOH patients whose serum testosterone was8~11.5nmol should underwent small dose testoserone therapy. |
