Systematic Review To Self-blood-point-injection Therapy Of Chronic Urticaria

Objective: Evaluating the efficacy and safety of Self-blood-point-injection therapy to chronic urticaria by using Cochrane Systematic Review.Provide the basis for Self-blood-point-injection therapy to chronic urticaria in clinical and research fieldsMethods: By searching Pub Med,Cochrane Library,Embase,CNKI,VIP,Wanfang,Sino Med,(the database set up day from December 2015).Collecting the RCTs studies which using Self-blood-point-injection therapy to treat chronic urticaria as wel as using blank,placebo or TCM or western medicin.Quality assessment and data extraction were finished by using the Cochrane Handbook 5.1.0.Using Rev Man 5.2 software Meta analysis.For the studies those which can not be analyzed by Meta analysis,we will analyze it one by one.Results: The final study included eight documents(eight randomized controlled trials),a total of 937 patients with CU.Studies included,5explicitly using a random number table generated random number sequence,3illustrate the use of randomized but did not mention which method is used to generate random number sequence.All studies were not mentioned allocation concealment.All studies reported markedly effective rate and total efficiency,six reported a recurrence rate of 6 documents mentioned adverse reactions.Point Autohemotherapy vs oral loratadine total of three studies compared the efficacy of the total CU efficiency markedly effective rate,recurrence rate,Meta analysis showed that the total effective rate [RR = 1.05,95% CI(0.97,1.13),P = 0.21],there was no significant difference;markedly effective rate[RR = 1.12,95% CI(0.98,1.28),P = 0.21] There was no significant difference;the recurrence rate RR = 0.10,95% CI(0.98,1.28),P <0.00001]difference was statistically significant,oral loratadine joint points recurrence rate from blood therapy for simple oral loratadine 1/10.Conclusion: Conclusion: The low methodological quality of the included studies,publication bias,while incorporating low quality literature,it affects the credibility of the results.But lower clinical evidence does not indicate that no practical,clinical applications of Self-blood-point-injection therapy to chronic urticaria need to combine clinical and technical level implementers patient's own conditions and willingness to consider.The exact effect of acupoint injection of blood from the treatment of chronic urticaria also requires a large sample,multi-center,randomized,double-blind controlled clinical trial to further confirm.