Effect Of Patients With Shuganliqi, Qingrehuayu Method To Evaluate The Treatment Of Post-stroke Anxiety And Effect On Brain-derived Neurotrophic Factor Levels

1 Objective The purpose of this study is to observe the clinical curative effect of anxiety patients after stroke with methods of shuganliqi,qingrehuayu,and the impact to serum level of brain derived neurotrophic factor.To preliminarily explore Mechanism of action in treating anxiety patients after stroke, with the method of shuganliqi,qingrehuayu.2 Methods Conform to the research standard of 80 cases of PSA patients, randomly assigned into treatment group(traditional chinese medicine combine with paroxetine therapy) and control group(paroxetine therapy), 40 cases in each.Rating for the score s,respectively before and after 2 weeks treatment, after 4 weeks and 8 weeks treatment,with Hamilton anxiety scale(HAMA) and neural function defect scale(NIHSS) score, Barthel index(BI) scale, Pittsburgh sleep quality scale(PSQI) and self-made TCM anxiety syndrome after stroke.Evaluation of clinical curative effect of shuganliqi,qingrehuayu in treatment of anxiety patients after stroke.And compare the change of two groups of serum brain derived neurotrophic factor(BDNF) before and after the treatment. And then discusses possible mechanism for the treatment of anxiety after stroke,with method of shuganliqi,qingrehuayu.3 Results The HAMA scores, NIHSS scores, PSQI scores and TCM syndrome scores after treatment in treatment group and control group were both less than before treatment,and the treatment group is better than the control group, the difference was statistically significant(P < 0.01);In the BI score, the treatment group and control group were both increased,controling to before treatment, and the treatment group is better than that of control group, the difference was statistically significant(P < 0.01).HAMA scores,after 2 weeks treatment, after 4 weeks treatment,after 8 weeks treatment,of the treatment group than the control group showing a downward trend, the difference was statistically significant(P < 0.01); And the NIHSS scores, BI scores, PSQI scores and TCM syndrome scores, comparisonbetween treatment group and the control group were statistically significant(P <0.01).Treatment group total effectiveness 85%, control group total effectiveness67.5%, treatment group total effective rate was higher than the control group significantly(P<0.01), the difference was statistically significant.Treatment group adverse reactions to the total incidence of 20%, the control group 40% incidence of adverse reactions to the total, the more similar between the two groups has no statistical significance(P > 0.05).Comparison of the serum levels of BDNF after 8weeks treatment,patients with PSA of treatment group was significantly increased to control group, and the comparison between treatment group and the control one was statistically significant(P < 0.01).4 Conclusion The effect of treating PSA with shuganliqi,qingrehuayu method combined anti-anxiety medicine was better than anti-anxiety medicine alone, which can obviously improve the HAMA score and TCM syndrome score, improve the sleep quality of patients, and can promote the recovery of neural function, at the same time can reduce the adverse reaction on western medicine therapy, high safety,clinical curative effect is remarkable.That the mechanism of action in trentment of PSA with shuganliqi, qingrehuayu combined paroxetine therapy methods is possible associated with changes of Brain derived neurotrophic factor level.