Establish The Animal Model Of Gastric Perforation And Application Of Polylactic Acid Sheets To Repair Of Gastric Defects

Background: The repair of defects in the upper gastrointestinal tract constitutes an integral part of gastrointestinal surgery and is usually accomplished through primary suturing. We repaired the digestive tract defects with a new biofilm,which uses a medical polymer absorbable material- polylactic acid as a raw material. It is similar in efficacy and safety to a traditional repair, for instance, surgery omentum or simple suture perforation. Objective: To test the efficacy of the polylactic acid patch for repairing full-thickness defects of the stomach wall. Methods: Circular defects,1.0 cm in diameter, were created on the anterior wall of the stomach of 20 New Zealand rabbits. The defects were repaired by an polylactic acid patch or omentum.Results: The animals survived the surgical procedure and underwent an uneventful recovery until euthanasia. No complications were seen in any of the rabbits. None of the patches failed. Perforation is similar to ulcer lesions, and gradually healing under Endoscopic observation. A histological examination showed gradual narrowing of the perforation site by mucosal and limited muscular regeneration. Conclusions: The polylactic acid patch successfully repaired a gastric defect in our experimental model,and it seems that the polylactic acid patch potentially served as a material suitable for further research concerning the repair efficacy of upper gastrointestinal defects.