Clinical Analysis Of 100 Cases Of Primary Hepatic Carcinoma Under 35 Years Old

Objective: The study of young people of primary liver cancer(male or female)gender,age,past history(hepatitis B or C),personal history(living in rural or city,whether drinking)and family history(with no lineal relatives of patients with hepatocellular carcinoma),and found the main clinical symptoms,serum AFP level,the concentration of serum ALT,serum concentration of AST and HBV markers,HBV DNA concentration,hepatic cirrhosis,radiological,pathological type,whether to accept antiviral therapy and received different treatment methods(Department of internal medicine,conservative treatment,interventional and surgical resection,liver transplantation)and other clinical data,clinical features for young people primary liver cancer,to explore the diagnosis and treatment strategy.Methods: This topic from affiliated Ruikang Hospital of Guangxi College of traditional Chinese medicine choice meets the project requirements from 2009 to 2012 and 100 cases of 35 years old of the following primary hepatocellular carcinoma patients were retrospectively analyzed,application of spss20.0 statistical software of 100 cases of primary hepatocellular carcinoma patients data for statistical analysis.Results: Gender: a total of 100 cases were collected,including 88 males(88%)and 12 female(12%).The ratio of male to female was 7.33:1.Age: the youngest 14 years old,the oldest 35 years old,the age of onset is mainly concentrated in 26 to 35 years old.36 cases(36%)had a history of alcohol drinking,27(27%)had a history of eating fish,and there were 6 cases(6%).46 cases(46%)living city,54 cases(54%)living in rural areas.92 cases(92%)had a history of chronic HBV infection,of which only 3(3%)were treated with anti viral therapy,and the patients without HCV infection were not found.59 cases(59%)had a family history of primary liver cancer,only 11 cases(11%)had no family history of primary liver cancer,the remaining 30 cases(30%)were not sure if there was a family history of primary liver cancer.32(32%)patients had a history of cirrhosis,68(68%)were not clear or have no history of cirrhosis.The most common finding was 59 cases(59%)of upper abdominal pain,Can occur in patients with different clinical symptoms,the main symptoms including abdominal pain,fever,fatigue,weight loss,abdominal distension,loss of appetite loss,hematemesis and melena,diarrhea and other symptoms,which the most common is 65 cases of abdominal pain(65.0%),followed by weight loss in 42 cases(42%).Signs enlargement of the liver,abdomen is wrapped block is most common for 40 cases(40.0%);followed by liver area kowtow attack painful 33 cases(33.0%),other signs respectively: signs of liver cirrhosis in 29 cases(29.0%),24 cases of jaundice(24.0%);ascites in 22 cases(22.0%),extrahepatic metastasis signs of 14 cases(14.0%);paraneoplastic syndrome in 11(11.0%).The results of imaging examination showed that: 55 cases(55%)block type,32 cases(32%)of nodular type,13 cases(13%)diffuse type,image classification and AFP expression with significant statistical difference.56 cases of patients with pathological type,which 36 cases(64.3%)for liver cell type,15 cases(26.8%)of bile duct cancer cell type,5 cases(8.9%)mixed cell type,histological type and AFP expression has significant statistical difference.Laboratory examination found that alpha fetoprotein(AFP)positive rate was 79%,no significant age and AFP expression in young patients,while the positive rate of AFP was higher for men and women.Alanine aminotransferase(ALT)and aspartate aminotransferase(AST)can increase the sensitivity of ALT is higher than AST.Hepatitis B markers showed small Sanyang patients up to 67 cases(67%),followed by 24 cases of HBeAg positive patients(24%).Hepatitis B virus DNA was positive in 78 cases(78).The treatment of only 24 patients had surgery treatment,the 1 cases of liver transplantation,surgical treatment rate of only 25%,most of the patients chose conservative treatment and interventional Department of internal medicine.Conclusions: Young primary hepatocellular carcinoma in terms of gender men far more than women,and the number of patients with the age increase.Young people in primary hepatocellular carcinoma(HCC)disease is the most common because of HBV infection,family history of liver cancer and chronic alcoholism also plays a very important role in the;the vast most patients without standardized antiretroviral treatment,diagnosis in advanced cancer,surgical resection rate is very low.Young people in primary hepatocellular carcinoma is the most common upper abdominal pain,common clinical symptom is abdominal pain,weight loss,abdominal distension,and common signs is abdominal block,liver area kowtow attack painful,signs of liver cirrhosis;among the radiological type,the block type was the most common;histological type in liver cell type most common.Youth human primary hepatocellular carcinoma(HCC)HBV-DNA positive were significantly higher than those of the negative and HBV replication and canceration exist certain relationship;most patients have elevated transaminase levels,but ALT sensitivity to higher than ast;small Sanyang patients is obviously higher than that in HBeAg positive patients,indicating that small Sanyang patients is not stable condition,do not need treatment,in fact,small Sanyang patients easily cancerous.AFP for diagnosis of young people in primary hepatocellular carcinoma(HCC)value is bigger;the expression of AFP by gender,pathological type,image type factors;in 35 years old the following primary hepatocellular carcinoma,AFP expression in every age group had no significant difference.