Clinical Observation Of Aspirin In Treatment Of Acute Cerebral Infarction After Cerebral Hemorrhage

Objective:By clinical investigating and analyzing acute cerebral infarction patients,cerebral hemorrhage in advance,by treatment with various dosage aspirin safety and effectiveness.Emphatically,I will discuss clinical advantages by using antiplatelet drugs-aspirin.Methods: Dividing 60 acute cerebral infarction patients,cerebral hemorrhage in advance,into two groups randomly,30 each: 100 mg aspirin-taken group and 50 mg aspirin-taken group.Both groups orally take daily.Two groups receive conventional therapies consists,give dehydration and reduce intracranial pressure;improve cerebral cell metabolism;scavenge oxygen free radicals;reduce blood lipid,blood pressure,blood sugar etc.comprehensive treatments.Both groups treat 28 days.Respectively,review National institute of health stroke scale(NIHSS)and Score of daily activity ability(Barthel Index)at pre – treatment,14 days after,28 days after and 6 months after;measure venous blood platelet count(PLT),mean platelet volume(MPV),mean platelet distribution width(PDW),fibrin original(FIB),prothrombin time(PT)and the function of lover and kidney at admission and 28 days;compare efficacy and influence,antiplatelet drugs on platelet parameters,observe drug diverse reactions.Both groups continuously take 50 mg and 100 mg aspirin orally daily after treatment finish.Following further consultation,by reviewing recurrence of cerebral hemorrhage and cerebral infarction during 6 months.Results:After 2 weeks of treatment,the NIHSS and Barthel Index scores in 100 mg aspirin-taken group were(6.03 ± 2.76)and(58.62 ± 10.08) respectively,but(8.13±3.17)and(57.67±10.15)in 50 mg aspirin-taken group.Both the differences were statistically significant(P <0.05).Those scores were also changed after 28 days.The high-dose group achieved scores were(3.90±2.99)and(64.66±9.72),while those were(7.03±3.31)and(58.17±9.14)in low-dose group.Unlike the results of 14 days ago,the scores of Barthel Index in 50 mg aspirin-taken group have no statistical difference(P>0.05).The efficiency of reatment group was 93.1%,which was significantly higher than that of 50 mg aspirin-taken group(46.6%).MPV and PDW,PLT in both groups were improved after 28 days of treatment,and 100 mg aspirin-taken group was statistically better than that of 50 mg aspirin-taken group(P <0.05).There are no statistical differences after treatment in FIB,PT,liver function and renal function(P>0.05).After six months follow-up,two groups in NIHSS score and Barthel index score have no obvious changes compared with 28 days after treatment.None of patients in 100 mg aspirin-taken group were relapse,but the 50 mg aspirin-taken had 2 cases of recurrence.Conclusion: Aspirin can treat cerebral hemorrhage after acute cerebral infarction,and 100 mg of aspirin-taken group were superior to 50 mg of aspirin-taken group;A history of bleeding in the brain of patients with acute cerebral infarction patients without cerebral hemorrhage and cerebral infarction after taking 100 mg of aspirin in six months follow-up.