The Preliminary Study On Elasticity Point Quantification Technology For Diagnosis And Differential Diagnosis Of Hysteromyoma From Adenomyoma

Objective: To assess the feasibility and value of quantitative parameters of elasticity point quantification(ElastPQ) in the differential diagnosis of hysteromyoma and adenomyoma by measuring the elasticity point quantification value of hysteromyoma, adenomyoma and some healthy people. Find out the quantitative criteria for the differential diagnosis of hysteromyoma and adenomyoma.Methods: 66 paitients with hysteromyoma, 55 paitients with adenomyoma in uterus and 98 normal people were collected from January 2015 to January 2016 in Fourth hospital of Hebei Medical University, these people were underwent both conventional ultrasonography and elasticity point quantification technique detection. All parameters were analyzed with SPSS 13.0 statistical software with appropriate statistical methods according to their features. Analyze the influence of age, position and different menstrual cycle on ElastPQ value on normal people. According to pathologic results, ROC curve was drawn to evaluate the best cutoff value in differentiating hysteromyoma and adenomyoma. The results of ElastPQ were compared with conventional ultrasound.Results: There was no significant difference of Elast PQ value among different ages, positions and menstrual cycle in normal uterus(P>0.05). According to the result of pathology, the mean ElastPQ value of 66 hysteromyoma and 98 normal people was26.16±11.55 kPa and 10.76±3.36 kPa, respectively.The median ElastPQ value of adenomyoma was7.65 kPa. The ElastPQ value among hysteromyoma, adenomyoma and normal uterus had significant differnce(P<0.05). On ROC curve, the area under the curve(AUC) of the ElastPQ value was 0.874. Taking 14.03 kPa as the best cutoff value of differentiate hysteromyoma and adenomyoma, the sensitivity, specificity positive predictive value, negative predictive value and Youden's index was86.4%, 90.9%, 91.9%, 84.7%, 0.694, respectively. At the same time the sensitivity, specificity, positive predictive value,negative predictive value and Youden's index of the conventional ultrasound was 89.4%, 83.0%, 69.4%, 86.3%, 0.843, respectively. The differential diagnosis accuracy for and adenomyoma of ElastPQ compared with conventional ultrasound had no significant difference(P>0.05).Conclusion: There is no significant difference of ElastPQ value between different ages, positions and menstrual cycle in normal uterus. ElastPQ can help differentiate hysteromyoma from adenomyoma to some extent by offering quantitative criteria for stiffness of tissue.