The Effect Of Atorvastatin Calcium On Renal Funtcion In Elderly Male Patients With Type 2 Diabetic Kidney Disease

Objective:The objective of this study was to investigate the effect of atorvastatin calcium(Lipitor:20mg/pill,Pfizer Batch No:H20051408) on renal funtcion in elderly male patients with type 2 diabetic kidney disease by calculating the changes of parameters, such as, estimated glomerular filtration(eGFR)?urinary albumin to creatinine ratio (ACR)?serum creatinine (Scr)?Blood Urea nitrogen(BUN)? (N-acetyl-(3-D-glocosaminidase(NAG). And this would be useful to the prevention and treatment of diabetic nephropathy.Method:Patients from Department of Geriatrics in the Second Affiliated Hospital of Chong Qing Medical University for the period from February 2013 to February 2015 (183 cases) were included. All the patients blood pressure below 150/90mmHg, glycated hemoglobin level below 7.0-9.0% Based on where or not treated with atorvastatin calcium, these patients were divided into control group,91 cases and intervention group,92 cases(treated with 20mg atorvastatin calcium for 6 months). And the intervention group were further divided into middle-aged group,20 cases,ages 45 to 59(49.4±6.5)?old-aged group,41 cases,60 to79(70.2±7.4)?elder group,31 cases,80-89(82.5±5.8).The following indicators were acquired by inquiring the case history and auxiliary examinations?General information:gender?age?history of smoking?the fasting(FBG) and 2h postprandial blood glucose(2hPG) determined by Enzyme Electrode Hemoglobin AlC(HbAlC) determined by Bioluminescence? body mass index (BMI)?waist-to-hip ratio (WHR)?average systolic(SBP) and diastolic blood pressure(DBP) by motoring 24-hour ambulatory blood pressure?total cholesterol(TC)?triglyceride(TG)?low density lipoprotein cholesterol(LDL-C)?high density lipoprotein cholesterol(HDL-C); 2.Indicators of adverse drug reaction:alanine aminotransferase(ALT)? aspartate aminotransferase(AST)?creatine kinase(CK); 3. Indicators of renal function:ACR by mesuring the first morning urine albumin and creatinine concentration?NAG?Scr?BUN. The eGFR was calculated by using MRDR equation. eGFR=175xScr-1.234x age-0.179 x [0.79(women)]We explored the effect of atorvastatin calcium on renal funtcion in elderly male patients with type 2 diabetic nephropathy by compare the change of parameters above before and after the intervention.Result:Six months later after atorvastatin calcium intervention, the indicators including ACR?BUN?NAG were decreased and HDL-C was increased comparing to control group (P<0.05); (2) Atorvastatin calcium intervention significantly decreased ACR?BUN?NAG in all the three subgroups and lowered Scr in old age and elder groups (P<0.05); (3) We observed no significantly change of eGFR between control group and old age group, also elder group (p>0.05); (4) No patient developed myopathy or muscle pain and rise of transaminase after intervention. Only one patient appeared mildly elevated CK. None of the patients with AST, ALT increased significantly.Conclution:Atorvastatin calcium can significantly reduce ACR?BUN? Scr and NAG inelderly male patients with type 2 diabetic nephropathy and may have protective effect on renal function.