Preparation And Characterization Of Nano-hydroxyapatite/Poly(DTH) Carbonate Composite

This paper focuses on the design of nano hydroxyapatite and poly（desminotyrosyl-tyrosine hexyl ester）carbonate.The n-HA/P（DTH）C composites and n-HA/P（DTH）C bone cement were obtained by combining the advantages of n-HA and P（DTH）C.The contents are as follows:（1）N-HA was prepared by the solution precipitation.The result indicated that n-HA was rod-like,and the grain dimension of it was 10-25nm×30-45nm.Structure and constituent of n-HA was similar to that of human bone apatite.Based on n-HA,strontium-substituted hydroxyapatite（Sr-HA）was obtained by microwave-assisted solution.Results show that Sr²⁺successed to access the HA of Sr-HA.Though lattice parameters of HA changed,the crystal structure was still the same with before.（2）P（DTH）C was prepared with L-tyrosine as raw material.It was got that weight-average molecular weight and number-average molecular weight of the obtained polymer were about 42000 and 27000,respectively.（3）The blending method was applied to get n-HA/P（DTH）C composites.Further,n-HA/P（DTH）C bone cement was prepared with citric acid as curing liquid.The result indicated that hydrogen bond was formed between n-HA and P（DTH）C;Comprssive strength of n-HA/P（DTH）C bone cement was up to 18.2Mpa by Electronic univerial testing machines;Simulation experiment in vitro and Implated experiment indicated that n-HA/P（DTH）C cement exhibited good bioactivity,biocompatibility,biodegradable and osteogenesis performance.