The Application Of Porous Core Shell Nanofibers On The Drug Release

Coaxial-electrospinning is a versatile method for preparing core-shell nanofibers.Drugs can be encapsulated into the core phase by using this technique.With increased efficiency and encapsulation rate,the burst release can be reduced and drug bioactivity can be protected.Polylactic-co-glycolic acid(PLGA)has been widely used in biomedical and tissue engineering because of its biocompatibility and biodegradability.When using chloroform(CF)/N,N-dimethyl formamide(DMF)mixture as spinning solvent,with the increase of high volatility solvent chloroform in the mixed solvent system,the surface of the nanofibers changed from smooth,crack to porous.This study focused on the fabrication,characterization and release properties of bovine serum albumin(BSA)loaded electrospun porous core shell structured nanofibers.During the electrospinning process,PLGA80/20(in mixture of Chloroform and DMF)was used in the shell,blended BSA and PEO solution(in water)was used in core.SEM images showed the morphologies of the BSA loaded core-shell nanofibers were same with the single electrospun PLGA nanofibers.And with the increase of high volatility solvent chloroform in the mixed solvent system,the morphology of the core-shell nanofibers changed from smooth,crack to porous.The TEM images,water contact angle and ATR-FTIR showed the ideal core shell structure.The BSA release results showed the BSA release could be controlled for 7 days when the ratio of CF and DMF was 9:1,and the porous structure could enhance the release properties of BSA.Besides,we studied the fabrication and release properties of paclitaxel(PTX)loaded electrospun porous core shell nanofibers.The same solvent of core solution and shell solution favored the electrospinning process significantly.SEM and TEM images showed the morphologies and core shell structure of nanofibers.However,the PTX release results were not very well due to unsuitable core materials.The selection and optimization of the core materials will be the research priorities for future study.