Preparation And Study Of Filament For 3d Printing Artificial Bone

According to statistics,there are more than 3 million people with bone defects or dysfunction in China every year,due to trauma fracture caused by traffic accidents and production safety accidents,degenerative diseases of the spine,bone tumors,bone tuberculosis,and ischemic necrosis of the femoral head and so on,whence a large amount of bone repair materials are urgently needed.Bone grafting has become the only graft with the largest demand for blood transfusion,and there has been a growing trend.The present bone graft material mainly includes autogenous bone,allograft bone,specially treated xenogeneic bone and artificial bone material,etc.The autogenous bone has the defect of limited source of bone and pain of bone after operation,and the postoperative complications of autogenous bone can reach 8%.There are some disadvantages such as immunogenicity and pathogenicity of allograft bone and xenogeneic bone.Therefore,they are not the most ideal materials for bone repair.3D printing technology can be repaired according to any type of tissue and organ defects,which opens up a new way for the ultimate realization of non-damage repair trauma and functional reconstruction.In this paper,the preparation of 3D printing artificial bone material was made by using nano-crystalline collagen-based hydroxyapatite(Nanohydroxyapatite/ polylactic acid),which was prepared by biomimetic synthesis,and the composite materials of nto and polylactic acid(PLA)were used to prepare 3D printed artificial bone material.In this paper,the method of 3D printing of fused deposition modeling(FDM)was used to prepare the artificial bone implant.At first,the high temperature properties of the composite wire of the nS/ PLA composite wire were studied.The properties of composite wire were analyzed by scanning electron microscopy(SEM),X-ray diffraction(XRD),Fourier Transform Infrared Spectrometer(FTIR),energy dispersive spectroscopy(EDS),thermal gravimetric analysis(TG)and differential scanning calorimetry(DSC).At the same time,the testing of mechanical properties and the verification of cell compatibility were carried out.Finally,it is confirmed that the non-major stress-bearing part can meet the requirement of 3D printing,can be formed at the printing temperature of 200 ℃,and the printed product has certain mechanical property,can meet the repairing of bone defects of the non-major stress parts,has good cell adhesion and cell compatibility.