The Modified Synthesis And Drug Release Properties Research Of The Different Ordered Mesoporous Silica

With the incidence of orthopedic diseases increased year by year,the repair of bone defects has become a hot topic of research.The mechanical properties and biocompatibility of polymer materials are poor.So we focus on the inorganic mesoporous materials.Due to the ordered pore structure,high pore volume,large specific surface area,excellent surface modification and good biocompatibility,mesoporous silica materials have been widely studied as an ideal drug release carrier recently.However,the surface of mesoporous silica material is rigid,which is hard to control the capacity of drug targeted release.Thus,modifying the surface of the silicon-based mesoporous material is an excellent method to obtain good drug release properties.The silicon-based mesoporous powder,named Mesoporous silica nanoparticles(MSNs),MCM-41 and SBA-15,which possess different ordered mesoscopic structure,were adopted as matrix in this paper.And then we used β-cyclodextrin with 1-methyl-1H-benzimidazole(MBI)as pH-sensitive nanovalves to load MXF in MXF-Phosphate buffered saline solution(PBS)with different concentrations.We studied the effects of three different mesoporous silica materials’ mesoscopic structure on the MXF uptake capacity and release capacity.Combined with the practical application of orthopedic trauma,we also researched the optimal drug release environment.The specific research content as followings:In the third chapter of this article,MSNs was fabricated by the sol-gel method,whose specific surface area was 1114.1 m2/g,and the BJH pore radius and particle size was 2.9 nm and 1-3 μm.We optimized the MSNs functionalized with pH-sensitive nanovalves for the delivery of the broad spectrum fluoroquinnlone moxifloxacin.We researched the effect of MXF concentration in MXF-PBS solution on MXF uptake capacity(wt%)and release capacity(wt%).We also researched the optimal drug release environment of pH-sensitive nanovalves.Researches showed that the optimal drug release environment is pH=5 and the MXF release capacity was 1.5%.The best MXF uptake capacity was 12.8% at the 30 m M of MXF.In the forth chapter of this article,the Cetyltrimethylammonium Bromide(CTAB)was used as template reagent to fabricate the MCM-41 powders with two-dimensional orderly six-party mesoscopic struture,whose specific surface area was 897.2 m2/g,and the pore diameter was 1.8 nm.The prepared moxifloxacin carrier not only shows a higher loading,but also presents a lower biotoxicity.What’ s more,the moxifloxacin carrier can release the drug at orthopedic trauma human environment of pH=5.The best MXF uptake capacity was 8.3% at the 20 mM of MXF and the biggest release capacity was 3.1%.In the fifth chapter of this article,the PEO-PPO-PEO(P123)was used as template reagent to fabricate the SBA-15 powders with rod-like mesoporous silica structure,whose specific surface area and the pore radius was 356.8m2/g and 11.2nm,respectively,and the diameter of the powder along the long axis was between 0.5 and 1 μm,and the diameter along the minor axis was between 0.2 and 0.4 μm.we researched the differences of MXF’s uptake capacity and release capacity among SBA-15,MSNs,and MCM-41.Researches showed that the best MXF uptake capacity was 12.8% and the biggest release capacity was 8.7%.In general,the sixth chapter of this paper summarizes the research results: the silicon-based mesoporous powder of MSNs,MCM-41 and SBA-15 with different ordered mesoscopic structures were chosen as the matrix in this paper.And then we successfully loaded the MXF though mesoporous silica nanoparticles functionalized with pH-sensitive nanovalves.